Uridine

Summary

Your night out with the friends may seem like a total bust when struggling with a hangover the next morning, but there may be more than one silver lining. Uridine, a cognitive enhancing nucleotide, is found in beer in high quantities. While you may get some uridine from beer, you will undoubtedly benefit more from the supplemental form free from crazy nights and intoxication.

The uridine supplement (often in the form of uridine monophosphate), is a nucleotide that can improve neuronal growth in the brain [1], which suggests it enhances general cognitive function. The same synaptic growth can help uridine to treat symptoms of Alzheimer’s disease [2].

Uridine is also a synergistic compound with fish oil and particularly DHA. Studies suggest only a small quantity of uridine with DHA can increase brain levels of phospholipids by up to 30% [3].

Also Known As

UDP, UMP

Editors’ Thoughts on Uridine

Uridine is promising in combination with DHA. I’ve never tried it, but the studies suggest to me that it is kind of a “secret weapon” of sorts in order to improve utilization of DHA within the brain. Given how important DHA is, I suspect uridine is a very small price to pay for general cognitive enhancement.

If my grandfather were still alive, I would recommend he take this in addition to the krill oil he was taking before he passed.

Mansal Denton, Nootropedia Editor

uridine

Benefits of Uridine

Usually the benefits of uridine discussed in the research are confined to memory and cognitive enhancement. However, some of the most prominent data suggests uridine benefits for depression and bipolar disorder. A 6 week trial of teenagers with depressive symptoms or bipolar disorder showed that daily uridine had positive results [4].

Of course, the major benefits of uridine are related to cognitive enhancement and learning. Uridine (especially in combination with DHA) can increase the levels of brain phosphatidylcholine, which is important for increasing synaptic function [5]. Beyond the synapses, uridine aids in neurite growth [6], which is useful for developing new connections within the brain.

These benefits (both synapses and neuronal growth) have significant downstream effects for treatment in a number of diseases. Patients with Alzheimer’s disease have compromised synaptic function [7] so uridine should theoretically improve symptoms of Alzheimer’s and other neurodegenerative diseases.

Finally, many people in the nootropic community find the main uridine benefit to be synergy with DHA (fish oil). When DHA is combined with only 0.5% uridine, it increases brain levels of phosphatidylcholine by up to 30% [8].

Side Effects of Uridine

Currently, there are not many known side effects of uridine. Some people anecdotally complain or question whether gout may be a side effect, but there is currently no evidence to suggest this.

As with adding any kind of supplement, there is the risk of gastrointestinal distress especially at doses above the recommended dosage.

Uridine Dosage

Some studies suggest using doses as high as 1000 mg (1 gram), but for the purposes of cognitive enhancement 150 mg of uridine monosphosphate 1-2 times per day (total of 300 mg) is recommended.

Try this uridine dosage before you add too much to your daily stack. You will find that a slow progression will be best for your body to adapt.

How and Where to Buy Uridine

Uridine monophosphate is neither popular nor rare so it is possible to find it at certain health food stores. It is better to buy uridine monophosphate online so you can find a more affordable (and safe) product, however.

Nootropedia has specific vendors that we research and examine for their quality and reputability. Nootropics Depot is a trusted vendor and our recommended source of uridine monophosphate. They sell the powder in disodium salt powder, which is 200 servings for less than $20. If you purchase uridine from Nootropics Depot you also have the added protection of their HPLC testing, which they do on all of their products.

Selected Community Experiences

Got some Uridine Monophosphate and have been taking it sublingually for a couple weeks now. Stuff is great! I’ve completely cut caffeine from my diet. The “energy” and alertness this stuff gives is way better. It’s a calm, stable, mental awakening. Nice mood lift and stabilization. Seems to (on an unpredictable basis) help me need less sleep.” [9] – beejangles

References (Click to Expand)
  1. http://www.ncbi.nlm.nih.gov/pubmed/10845757
  2. http://www.ncbi.nlm.nih.gov/pubmed/12399581
  3. http://www.ncbi.nlm.nih.gov/pubmed/16631143
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080753/
  5. http://www.ncbi.nlm.nih.gov/pubmed/17717139
  6. http://www.ncbi.nlm.nih.gov/pubmed/11722606
  7. http://www.ncbi.nlm.nih.gov/pubmed/12399581
  8. http://www.ncbi.nlm.nih.gov/pubmed/16631143
  9. https://www.reddit.com/r/Nootropics/comments/33idoz/uridine_cant_believe_i_havent_tried_this_stuff/
Other Scientific Resources (Click to Expand)
  1. http://www.ncbi.nlm.nih.gov/pubmed/22432687
  2. http://www.ncbi.nlm.nih.gov/pubmed/12370853
  3. http://www.ncbi.nlm.nih.gov/pubmed/16448171
  4. http://www.ncbi.nlm.nih.gov/pubmed/8676214
  5. http://www.ncbi.nlm.nih.gov/pubmed/8947961
  6. http://www.ncbi.nlm.nih.gov/pubmed/18803968
  7. http://www.ncbi.nlm.nih.gov/pubmed/11786646
  8. http://www.ncbi.nlm.nih.gov/pubmed/16673211
  9. http://www.ncbi.nlm.nih.gov/pubmed/18600512
  10. http://www.ncbi.nlm.nih.gov/pubmed/23480256
  11. http://www.ncbi.nlm.nih.gov/pubmed/3663397
  12. http://www.ncbi.nlm.nih.gov/pubmed/6726230
  13. http://www.ncbi.nlm.nih.gov/pubmed/21379380
  14. http://www.ncbi.nlm.nih.gov/pubmed/12084455
  15. http://www.ncbi.nlm.nih.gov/pubmed/1999851
  16. http://www.ncbi.nlm.nih.gov/pubmed/15821404
  17. http://www.ncbi.nlm.nih.gov/pubmed/8687475
  18. http://www.google.com/patents/US6258795
  19. http://www.ncbi.nlm.nih.gov/pubmed/11021741
  20. http://www.ncbi.nlm.nih.gov/pubmed/10354618
  21. http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1971.tb03744.x/abstract
  22. http://www.ncbi.nlm.nih.gov/pubmed/1138930
  23. http://www.ncbi.nlm.nih.gov/pubmed/12838422
  24. http://www.ncbi.nlm.nih.gov/pubmed/9803833
  25. http://www.ncbi.nlm.nih.gov/pubmed/12856181
  26. http://www.ncbi.nlm.nih.gov/pubmed/14965251
  27. http://www.ncbi.nlm.nih.gov/pubmed/16265592
  28. http://www.ncbi.nlm.nih.gov/pubmed/20503434
  29. http://www.ncbi.nlm.nih.gov/pubmed/15052332
  30. http://www.ncbi.nlm.nih.gov/pubmed/23010477
  31. http://www.ncbi.nlm.nih.gov/pubmed/15003397
  32. http://www.ncbi.nlm.nih.gov/pubmed/20651826

Author

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