Your night out with the friends may seem like a total bust when struggling with a hangover the next morning, but there may be more than one silver lining. Uridine, a cognitive enhancing nucleotide, is found in beer in high quantities. While you may get some uridine from beer, you will undoubtedly benefit more from the supplemental form free from crazy nights and intoxication.
The uridine supplement (often in the form of uridine monophosphate), is a nucleotide that can improve neuronal growth in the brain , which suggests it enhances general cognitive function. The same synaptic growth can help uridine to treat symptoms of Alzheimer’s disease .
Uridine is also a synergistic compound with fish oil and particularly DHA. Studies suggest only a small quantity of uridine with DHA can increase brain levels of phospholipids by up to 30% .
Also Known As
Editors’ Thoughts on Uridine
Uridine is promising in combination with DHA. I’ve never tried it, but the studies suggest to me that it is kind of a “secret weapon” of sorts in order to improve utilization of DHA within the brain. Given how important DHA is, I suspect uridine is a very small price to pay for general cognitive enhancement.
If my grandfather were still alive, I would recommend he take this in addition to the krill oil he was taking before he passed.
Mansal Denton, Nootropedia Editor
Benefits of Uridine
Usually the benefits of uridine discussed in the research are confined to memory and cognitive enhancement. However, some of the most prominent data suggests uridine benefits for depression and bipolar disorder. A 6 week trial of teenagers with depressive symptoms or bipolar disorder showed that daily uridine had positive results .
Of course, the major benefits of uridine are related to cognitive enhancement and learning. Uridine (especially in combination with DHA) can increase the levels of brain phosphatidylcholine, which is important for increasing synaptic function . Beyond the synapses, uridine aids in neurite growth , which is useful for developing new connections within the brain.
These benefits (both synapses and neuronal growth) have significant downstream effects for treatment in a number of diseases. Patients with Alzheimer’s disease have compromised synaptic function  so uridine should theoretically improve symptoms of Alzheimer’s and other neurodegenerative diseases.
Finally, many people in the nootropic community find the main uridine benefit to be synergy with DHA (fish oil). When DHA is combined with only 0.5% uridine, it increases brain levels of phosphatidylcholine by up to 30% .
Side Effects of Uridine
Currently, there are not many known side effects of uridine. Some people anecdotally complain or question whether gout may be a side effect, but there is currently no evidence to suggest this.
As with adding any kind of supplement, there is the risk of gastrointestinal distress especially at doses above the recommended dosage.
Some studies suggest using doses as high as 1000 mg (1 gram), but for the purposes of cognitive enhancement 150 mg of uridine monosphosphate 1-2 times per day (total of 300 mg) is recommended.
Try this uridine dosage before you add too much to your daily stack. You will find that a slow progression will be best for your body to adapt.
How and Where to Buy Uridine
Uridine monophosphate is neither popular nor rare so it is possible to find it at certain health food stores. It is better to buy uridine monophosphate online so you can find a more affordable (and safe) product, however.
Nootropedia has specific vendors that we research and examine for their quality and reputability. Nootropics Depot is a trusted vendor and our recommended source of uridine monophosphate. They sell the powder in disodium salt powder, which is 200 servings for less than $20. If you purchase uridine from Nootropics Depot you also have the added protection of their HPLC testing, which they do on all of their products.
Selected Community Experiences
“Got some Uridine Monophosphate and have been taking it sublingually for a couple weeks now. Stuff is great! I’ve completely cut caffeine from my diet. The “energy” and alertness this stuff gives is way better. It’s a calm, stable, mental awakening. Nice mood lift and stabilization. Seems to (on an unpredictable basis) help me need less sleep.”  – beejangles
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