Last updated: June 28, 2018


Tianeptine is a powerful synthetic chemical compound that is used to treat major depressive disorder. For people struggling with anxiety or mild depression, it can have significant mood enhancing effects [1] in addition to a number of other benefits.

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The drug was developed by French scientists in the 1960s and is a prescription drug for the purposes of treating depression in many countries around the world. Lately, nootropics users and the community at large has adopted tianeptine as a cognitive enhancer and alternative to other illicit substances.

Beyond use as an antidepressant, tianeptine is a powerful anxiolytic that can help patients with Parkinson’s disease [2] and even post-traumatic stress disorder [3]. Although powerful as a solution to these medical conditions, there are rare associated side effects like headaches, dry mouth, and dizziness.

Also Known As

Stablon, Coaxil, Tatinol, Tianeurax, Salymbra

Editors’ Thoughts on Tianeptine

A friend recently told me that his mother was struggling with anxiety and depression so he got her tianeptine and it solved a host of her mood related problems. While this is a single successful anecdote for the drug, it means more to me that my friend (who is very knowledgeable) trusted tianeptine so much that he recommended it for his own mother.

In most situations I would take something myself before I recommend my mother take it especially if she can be influenced by me or believes me. It is a responsibility that has gravity, which is why it’s so surprising to me.

I’ve never tried tianeptine myself, but everything I have heard is positive. I’m not really an anxious or depressed person in general.

Mansal Denton, Nootropedia Editor


Benefits of Tianeptine

The tianeptine benefits include anti-anxiety and antidepressant properties. The drug can be used for mild forms of anxiety, but it seems to have efficacy for the most treatment resistant disorders. Tianeptine shows comparable results to major prescription drugs in the treatment of serious depressive disorder, but with a fraction of the side effects [4].

This treatment of depression goes beyond the average person struggling with this disorder. One study of Parkinson’s patients showed a 77% improvement in mental status among tianeptine users [5]. The drug helped patients in dire circumstances to overcome their feelings of depression. The same phenomenon is true of PTSD. Patients suffering from PTSD showed a 75.6 and 76.7% response rate to tianeptine [6].

Beyond depression, the benefits of tianeptine expand to panic disorders as well. One study showed tianeptine could block panic attacks from occurring [7]. There are other positive effects of tianeptine including treating pain associated with fibromyalgia, treatment of depression in men with erectile dysfunction [8], and even mild efficacy for ADHD [9].

Side Effects of Tianeptine

Tianeptine interacts with many parts of the brain including the opiod receptors, which can create the side effect of euphoria [10]. Other side effects with varying frequency include the following [11][12][13]:

  • Headache (up to 18%)
  • Dizziness (up to 10%)
  • Insomnia / night terrors (up to 20%)
  • Drowsiness (up to 10%)
  • Dry mouth (up to 20%)

Other side effects include things like constipation, nausea, or anxiety. More severe concerns include withdrawal after abuse and an estimated 0.1 – 0.3% of users will have this problem. As you can see, the side effects of tianeptine are going to depend on the individual and personal biochemistry.

Tianeptine Dosage

The tianeptine dosage will depend upon the product that you purchase. If you buy tianeptine powder you must know whether it is sodium or sulfate. Tianeptine sodium powder is usually consumed in doses of 12.5 mg in three separate doses per day. Tianeptine sulfate can be consumed in 1 – 2 doses of 25 mg per day.

Some people take 25 mg capsules so as to get a more complete dose. If you are taking tianeptine sodium powder, keep in mind that it is lower in potency and higher absorption and excretion.

Tianeptine and Nootropic Stacks

In most situations, there is an opportunity to use nootropics in combination with one another. When it comes to taking depression or medications as strong as tianeptine that alter mood, it is actually more important to get a warning about the interactions that some drugs might have with others.

For example, there are over 40 ingredients in the Qualia blend. Although this blend is well-reviewed and developed, combining it with powerful drugs like tianeptine can be a bad idea because of the interactions. The same can be true for other popular unique blends like alpha brain, OptiMind, and truBrain. Some of the more natural stacks like Four Sigmatic mushroom coffee or Mind Lab Pro might be okay, but proceed with caution.

The same is true (but to a lesser degree) of other nootropics like piracetam, aniracetam, and the entire racetam family. There is less of a risk because these are individual ingredients that you can test by yourself, but are nonetheless still dangerous. With highly stimulating drugs like phenylpiracetam, it is important to consider these interactions.

Finally, it is even more important to not try stacking drugs that are mood enhancers. Some people believe that adding St John's wort or other anxiety related drugs will be beneficial, but more is not always better.

How and Where to Buy Tianeptine

Tianeptine typically comes in two forms and you will find neither of them in your local health food store. In order to buy tianeptine online, make sure you have a reliable vendor that you trust. One way to know that you have a trusted vendor is to look for HPLC testing so that you are sure the product is safe.

  • Tianeptine Sulfate – You will want to buy tianeptine sulfate if you live in humid climates. This is a more stable compound with moisture whereas the other form of tianeptine supplement is not. The sulfate form is higher in potency as well.
  • Tianeptine Sodium– This is a lower potency, but quicker absorbing tianeptine option with a fast excretion rate as well. It is hydroscopic, which means it can clump with moisture in the air.

If you are new to tianeptine, we suggest you just go with tianeptine sulfate and there are capsules to use for your convenience as well.

Selected Community Experiences

So I've been a regular user of Tianeptine for about 2 months already. It's an amazing compound. I can literally see my mood go from poopy and irritable to feeling good. It makes me more talkative and happy in general. My two favorite places to get them from are ceretropic and powdercity. They both are quality. So anyways, I decided to try Ceretropic's new tianeptine sulfate powder. It claims it last longer and tastes much better. Well I received it in the mail 4 days ago. I've been using it right when I wake up at 6am everyday and it will last me all the way into the late afternoon, then I'll redose one more time and then it will last me till bedtime. I'm taking 25mg per dose. The difference from the regular tianeptine is that there is no sudden spike of euphoria, just a smooth onset and a very smooth treatment till it wears off. It will keep you feeling balanced.” [14] – vicnguyen1978

Nootropedia Disclaimer: While we support psychedelic science and support usage of entheogens like ayahuasca (DMT) and psilocybin, it is recommended to avoid using other substances such as tianeptine alongside them. We do not recommend using them together. 

References (Click to Expand)
  1. //www.ncbi.nlm.nih.gov/pubmed/2902922
  2. //www.ncbi.nlm.nih.gov/pubmed/17457538
  3. //www.ncbi.nlm.nih.gov/pubmed/16329631
  4. //www.ncbi.nlm.nih.gov/pubmed/11463130
  5. //www.ncbi.nlm.nih.gov/pubmed/17457538
  6. //www.ncbi.nlm.nih.gov/pubmed/16329631
  7. //www.ncbi.nlm.nih.gov/pubmed/15582922
  8. //www.ncbi.nlm.nih.gov/pubmed/16942535
  9. //www.ncbi.nlm.nih.gov/pubmed/15034228
  10. //www.ncbi.nlm.nih.gov/pubmed/18311558
  11. //www.ncbi.nlm.nih.gov/pubmed/11463130
  12. //www.ncbi.nlm.nih.gov/pubmed/18072812
  13. //www.ncbi.nlm.nih.gov/pubmed/11772119
  14. //www.reddit.com/r/Nootropics/comments/2zyaqp/props_to_ceretropic_for_making_the_new_tianeptine/


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