Last updated: March 14, 2017


Tianeptine is a powerful synthetic chemical compound that is used to treat major depressive disorder. For people struggling with anxiety or mild depression, it can have significant mood enhancing effects [1] in addition to a number of other benefits.

The drug was developed by French scientists in the 1960s and is a prescription drug for the purposes of treating depression in many countries around the world. Lately, nootropics users and the community at large has adopted tianeptine as a cognitive enhancer and alternative to other illicit substances.

Beyond use as an antidepressant, tianeptine is a powerful anxiolytic that can help patients with Parkinson’s disease [2] and even post-traumatic stress disorder [3]. Although powerful as a solution to these medical conditions, there are rare associated side effects like headaches, dry mouth, and dizziness.

Also Known As

Stablon, Coaxil, Tatinol, Tianeurax, Salymbra

Editors’ Thoughts on Tianeptine

A friend recently told me that his mother was struggling with anxiety and depression so he got her tianeptine and it solved a host of her mood related problems. While this is a single successful anecdote for the drug, it means more to me that my friend (who is very knowledgeable) trusted tianeptine so much that he recommended it for his own mother.

In most situations I would take something myself before I recommend my mother take it especially if she can be influenced by me or believes me. It is a responsibility that has gravity, which is why it’s so surprising to me.

I’ve never tried tianeptine myself, but everything I have heard is positive. I’m not really an anxious or depressed person in general.

Mansal Denton, Nootropedia Editor


Benefits of Tianeptine

The tianeptine benefits include anti-anxiety and antidepressant properties. The drug can be used for mild forms of anxiety, but it seems to have efficacy for the most treatment resistant disorders. Tianeptine shows comparable results to major prescription drugs in the treatment of serious depressive disorder, but with a fraction of the side effects [4].

This treatment of depression goes beyond the average person struggling with this disorder. One study of Parkinson’s patients showed a 77% improvement in mental status among tianeptine users [5]. The drug helped patients in dire circumstances to overcome their feelings of depression. The same phenomenon is true of PTSD. Patients suffering from PTSD showed a 75.6 and 76.7% response rate to tianeptine [6].

Beyond depression, the benefits of tianeptine expand to panic disorders as well. One study showed tianeptine could block panic attacks from occurring [7]. There are other positive effects of tianeptine including treating pain associated with fibromyalgia, treatment of depression in men with erectile dysfunction [8], and even mild efficacy for ADHD [9].

Side Effects of Tianeptine

Tianeptine interacts with many parts of the brain including the opiod receptors, which can create the side effect of euphoria [10]. Other side effects with varying frequency include the following [11][12][13]:

  • Headache (up to 18%)
  • Dizziness (up to 10%)
  • Insomnia / night terrors (up to 20%)
  • Drowsiness (up to 10%)
  • Dry mouth (up to 20%)

Other side effects include things like constipation, nausea, or anxiety. More severe concerns include withdrawal after abuse and an estimated 0.1 – 0.3% of users will have this problem. As you can see, the side effects of tianeptine are going to depend on the individual and personal biochemistry.

Tianeptine Dosage

The tianeptine dosage will depend upon the product that you purchase. If you buy tianeptine powder you must know whether it is sodium or sulfate. Tianeptine sodium powder is usually consumed in doses of 12.5 mg in three separate doses per day. Tianeptine sulfate can be consumed in 1 – 2 doses of 25 mg per day.

Some people take 25 mg capsules so as to get a more complete dose. If you are taking tianeptine sodium powder, keep in mind that it is lower in potency and higher absorption and excretion.

How and Where to Buy Tianeptine

Tianeptine typically comes in two forms and you will find neither of them in your local health food store. In order to buy tianeptine online, make sure you have a reliable vendor that you trust. One way to know that you have a trusted vendor is to look for HPLC testing so that you are sure the product is safe.

  • Tianeptine Sulfate – You will want to buy tianeptine sulfate if you live in humid climates. This is a more stable compound with moisture whereas the other form of tianeptine supplement is not. The sulfate form is higher in potency as well.
  • Tianeptine Sodium– This is a lower potency, but quicker absorbing tianeptine option with a fast excretion rate as well. It is hydroscopic, which means it can clump with moisture in the air.

If you are new to tianeptine, we suggest you just go with tianeptine sulfate and there are capsules to use for your convenience as well.

Selected Community Experiences

So I’ve been a regular user of Tianeptine for about 2 months already. It’s an amazing compound. I can literally see my mood go from poopy and irritable to feeling good. It makes me more talkative and happy in general. My two favorite places to get them from are ceretropic and powdercity. They both are quality. So anyways, I decided to try Ceretropic’s new tianeptine sulfate powder. It claims it last longer and tastes much better. Well I received it in the mail 4 days ago. I’ve been using it right when I wake up at 6am everyday and it will last me all the way into the late afternoon, then I’ll redose one more time and then it will last me till bedtime. I’m taking 25mg per dose. The difference from the regular tianeptine is that there is no sudden spike of euphoria, just a smooth onset and a very smooth treatment till it wears off. It will keep you feeling balanced.” [14] – vicnguyen1978

References (Click to Expand)
  1. //www.ncbi.nlm.nih.gov/pubmed/2902922
  2. //www.ncbi.nlm.nih.gov/pubmed/17457538
  3. //www.ncbi.nlm.nih.gov/pubmed/16329631
  4. //www.ncbi.nlm.nih.gov/pubmed/11463130
  5. //www.ncbi.nlm.nih.gov/pubmed/17457538
  6. //www.ncbi.nlm.nih.gov/pubmed/16329631
  7. //www.ncbi.nlm.nih.gov/pubmed/15582922
  8. //www.ncbi.nlm.nih.gov/pubmed/16942535
  9. //www.ncbi.nlm.nih.gov/pubmed/15034228
  10. //www.ncbi.nlm.nih.gov/pubmed/18311558
  11. //www.ncbi.nlm.nih.gov/pubmed/11463130
  12. //www.ncbi.nlm.nih.gov/pubmed/18072812
  13. //www.ncbi.nlm.nih.gov/pubmed/11772119
  14. //www.reddit.com/r/Nootropics/comments/2zyaqp/props_to_ceretropic_for_making_the_new_tianeptine/


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  • Hungry Chemist

    Sorry (not sorry) to be a pedant, but the word is not ‘hydroscopic’, but ‘hygroscopic’. I know, it’s stupid, given that hydrophillic and hydrophobic are words, but that’s the world of chemistry.

    • Mansal Denton

      Hey there, don’t be sorry! Thanks for the clarification. Where does it say hydroscopic, though? In the video? I don’t see it in the text…

      • Michael Koutsouris

        It’s in the Tianeptine Sodium description.

        • Mansal Denton

          D’oh! Thanks for spotting that Michael 🙂 I have just changed it.

  • LopLover Rescue

    I was recommended this for sleep by a friend who uses it when she’s desperate. None of the regular sleep medicines, including the prescription ones, work for her or me, so I was thinking of trying it. Two issues, though. I don’t see much about it helping insomnia in most people for one, although it’s anti-anxiety effect would also be nice. I’m not looking at it for anything but a very occasional use, which brings me to the second issue. I already am prescribed Effexor for depression. I have a life-long history of major depressive illness and used to try to kill myself pretty regular until the SSRI drugs were invented. I’ve been on most, and while Effexor is a bit speedy and stimulating, it has kept me grounded and out of the hospital now for about 10 years, way longer than anything else ever has. My doctor doesn’t want to prescribed any anxiety drugs or sleepers as I have a history with them, so all he has offered me is to switch me from Effexor to something else, and I don’t want to go through that again. Thoughts? I don’t want to do something that is going to affect my sanity; I’d just like a decent night’s sleep once in a while. Thanks!