Last updated: March 15, 2019
The name alone might be scary, but do not worry, PRL-8-53 may not be as bad as it seems. Although the evidence is scarce, there are signs this synthetic nootropic compound may be able to improve learning ability and memory formation .
One of the few studies that exists shows incredible promise for the drug, though obviously requires more analysis. In this study, supplementation of PRL-8-53 improved memory formation 87.5 – 105%. Those over the age of 30 saw improvements of 108 – 152% .
Unfortunately, the drug is confounded because the lone trials are done by the patent holders with a vested interest in the success of this synthetic compound.
Also Known As
Editors’ Thoughts on PRL-8-53
The percentage increases with this nootropic look promising, but obviously more research is needed. I would not feel comfortable taking the drug, but it is experimental with plenty of people in the nootropics community raving about it. It was also used on humans so that may be useful in determining the efficacy or safety.
Optimistically skeptical on this one.
Mansal Denton, Nootropedia Editor
The benefits of PRL-8-53 aren’t fully known, but it is generally considered to be a memory and learning enhancer. In the lone study with rats, taking PRL-8-53 120 – 150 minutes before a cognitive test helped drastically. Memory was tested at 24 hours after dosing and 96 hours with positive results compared to a placebo .
Within these tests, some of the test performance improvements were in the range of 80 – 100+%, which suggests significant potential.
The study separated the analysis of memory and “working memory”, which showed less improvement, but still notable.
PRL-8-53 Side Effects
According to the evidence with rats, PRL-8-53 seems to be a dopamine agonist . This means that it can improve dopamine receptors and is often used in Parkinson’s patients. For people who do not need this feature, it could be an unwanted side effect of PRL-8-53.
The toxicity studies in rats show a relatively high threshold with LD50 rates, but obviously further evidence is needed. Also, it seems a potential side effect of PRL-8-53 is a reduction in motor activity within the brain .
How and Where to Buy PRL-8-53
There are not many places you can buy PRL-8-53 online, but luckily a Nootropedia recommended supplier called Ceretropic has the product for sale. Ceretropic takes precautions to test their products via HPLC and other biochemical testing to ensure it is of the highest quality. You can purchase PRL-8-53 here.
Selected Community Experiences
“I started out with small doses and worked my way up to larger quantities. I definitely feel that 10mg is a great everyday dose and it didn't seem like taking 15mg was a big improvement over the 10. However, I decided to try 20mg on Friday for my Neuroscience test and was amazed by the enhancement in recall I had. Up to that point I had not really felt too big improvement in memory or recall, but after that test I knew that it was working. For me I felt that the larger doses definitely helped on recall and was a huge help for tests. Also it seems that it is best taken 30 minutes before whatever you need it for Overall I definitely saw results and had no issues with with other nootropics that I take regularly.”  – baliflipper
“I've tried a variety of dosages of PRL-8-53, the so called ‘hypermnesic' varying from 5mg to 40mg orally, and 5-20mg sublingually. This is over the course of 2 months, and there seems to be no effect. I don't know if this is just my response and that it doesn't work for me, but there is no noticeable difference in my memory/cognition when testing with the Cambridge Brain Sciences website, as well as the Dual-n-back game.”  – m4nce
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