Pramiracetam

Summary

Pramiracetam was once touted as the latest and greatest within the racetam family. Given the nightmarish taste and alternatives, it has fallen from such a high esteem, but still remains one of the unique, potent, and effective nootropic compounds.

Like most smart drugs in the racetam family, pramiracetam is known to improve memory formation and learning ability [1]. In contrast with some of the other racetams, pramiracetam has been tested on healthy adults instead of merely focusing on elderly who are already losing their cognitive abilities. Specifically, pramiracetam helps to develop long-term memory in these trials [2].

Perhaps best of all, pramiracetam is a neuroprotective agent [3]. Pramiracetam can prevent cognitive decline and loss of memory in studies that looked at brain trauma. While more evidence is needed in this regard, every elderly person might have a closer look at this.

It tastes so bad, it must be good! Given that most people believe it tastes like fish scales, it is worthwhile to buy pramiracetam capsules as opposed to raw powder. Your tongue will thank us and if you don’t believe it, check out the Selected Community Experiences below.

Also Known As

CI-879, Diisoprop-yl-(2-oxopyrrolidin-1-yl)acetamide, CI879

Editors’ Thoughts on Pramiracetam

Do NOT buy the power. Just don’t do it.

If for some reason you end up with the powder, do your very best to combine it with others and shove it down your gullet quickly. It’s like a combination of fish scales, burning fire, and acid. However…

The effects are actually pretty nice. You’ll find that it is more stimulating than aniracetam or oxiracetam and is not as much as phenylpiracetam. Somewhat of a happy medium between the two and is great for both cognitive function / clarity and concentration. I’ve been mostly impressed with pramiracetam, but I would recommend not making the mistake of buying powder.

The capsules are only a bit more expensive, but believe me they will be well worth the added expenditure. Not all nootropics taste poorly (in fact, many of the racetams taste sweet), but this is the ugly step-child of racetams flavor-wise.

Mansal Denton, Nootropedia Editor

Pramricatam

Pramiracetam Benefits

If you have ever been in a work or personal situation where you had words, thoughts, or an answer on the tip of your tongue, but couldn’t remember, welcome to the human race. Just about every human has had this experience forgetting things.

Pramiracetam studies suggest one of the main benefits is for decreasing forgetfulness [4]. While this might look similar to improving memory (just two sides of the same coin?), in fact this has a completely different meaning. In this study, the participants were given a chemical called scopolamine, which induces amnesia in order to test the efficacy of a drug.

In this case, the pramiracetam benefit was clear: even when a “forgetfulness” agent was given to subjects, they still managed to remember at a similar rate as before. This neuroprotective benefit of pramiracetam helps the elderly, but healthy adults can see benefits to.

One major study looked at youth cognitive ability and concluded that amongst those with brain trauma, pramiracetam was able to improve cognitive abilities (such as learning) [5]. Given that brain trauma often comes in the form of athletic events, dehydration, lack of sleep, or substance abuse, there is a high percentage of people that could use the benefits of pramiracetam to reverse these trends.

How Does Pramiracetam Work?

Pramiracetam might be newer than many of the other neuro enhancers in the family, but that doesn’t mean it is poorly researched. Developed first in 1984 [6], pramiracetam has many potential mechanisms of action (i.e: how pramiracetam works) similar to that of the others in this family.

One major way pramiracetam works is by altering brain wave function in order to help improve cognitive abilities [7]. Pramiracetam is also able to improve memory formation and learning through a process called high-affinity choline uptake (HACU) [8]. This is a fancy way of saying pramiracetam helps produce more brain chemicals that aid in memory. Because of the slight change in the chemical structure of this drug, there are quite large changes to the efficacy.

If you’re wondering “how does pramiracetam work compared to piracetam?” the answer is: better. At least in some regards (such as amnesia / brain trauma), pramiracetam is more potent than piracetam [9].

Not to worry if some of this material is confusing. Just know that there are slightly different ways pramiracetam can help improve your brain health, but many are similar as the parent racetam drugs.

Pramiracetam Side Effects

Ah yes, what are the downsides of pramiracetam? Beyond the horrid taste, pramiracetam side effects might include burning and irritation within your throat and esophagus. Even though it is not life threatening, it is an extremely uncomfortable side effect of pramiracetam.

Other than the taste and accompanying burning, the side effects of pramiracetam are somewhat similar to that of racetams in general. This includes a headache if your brain chemistry is running low on choline. While this is not a confirmed or researched phenomenon, it is one that community members often remark on.

Additionally, you might find pramiracetam causes nausea, irritability, or insomnia if you take it too late in the day. Because pramiracetam is somewhat stimulating, it might keep you up at night!

Pramiracetam Dosage

Like any nootropic, the pramiracetam dosage will vary from person to person. It is suggested that you take 300 mg twice per day (600 mg total), but recommendation ranges go all the way up to 1200 mg per day.

There are no human trials that point to 1200 mg as the optimal dosage, but it is probably better to start at the lower end and move upward as you see fit and it works well with your brain chemistry.

How and Where to Buy Pramiracetam

As we have made clear in other sections of this article, pramiracetam is an effective and researched nootropic, but not one you’d like to consume in powder form. Make sure you buy pramiracetam powder only in the last / worst case scenario. For every other pramiracetam purchase, ensure you are getting capsules instead.

Pramiracetam capsules are far more convenient for adding into your nootropic stack and they will reduce the chances of inconvenient side effects, which plague most people who utilize the bulk pramiracetam powder.

Beyond the pramiracetam powder vs. capsules debate, this is another racetam product, which is unregulated by the U.S. Food and Drug Administration. Because it is unregulated, it is up to the vendors to provide adequate support and safety precautions. To that end, it is best to purchase pramiracetam from vendors who are willing to share information regarding the quality of their ingredients.

Namely, you’d be well off focusing on two main things:

  1. Assay
  2. Heavy metals

Both of these will give you peace of mind and prevent some of the ill-health effects that have plagued other members of the nootropics community.

Selected Community Experiences

Took some of the Pramiracetam this morning, my first taste of a nootropic outside of 5-HTP. It was the worst tasting shit I ever tasted, it tasted like toxic waste, but I liked that because I knew it must be some potent stuff…My brain never has worked this well. I was super focused…It was like that feeling you get when you are in that state at a party where you can do no wrong and have complete trust in your faculties and you are the fucking man- the life of the party. There was hardly any background noise. Thoughts were clearer” [10]. – Lurkin_Dirty

So far, I’m satisfied, especially with the Pramiracetam capsules. I heard that they were fat-soluble so I learned to take said capsules with Multi-Grain bread laced with Omega-3 fatty acids. As much as I feel a boost in clarity, I feel as if I want to tackle so many things at once but can’t seem to decide on what to tackle. I did work on two critical abstracts for one of my history classes back to back, and I’m eager to start on this essay for another class. I find pramiracetam to be very powerful, and I want to look into getting some choline to enhance the effects.” [11] – WhitePhantom77

took the pramiracetam during the day for classes, then started drinking about four hours later. My tolerance was GONE, lowered even. Just a word of advice.” [12] – Flamewall26

References (Click to Expand)
  1. //www.ncbi.nlm.nih.gov/pubmed/18653001
  2. //www.ncbi.nlm.nih.gov/pubmed/3088666
  3. h//www.ncbi.nlm.nih.gov/pubmed/6716406
  4. //www.ncbi.nlm.nih.gov/pubmed/15374306
  5. //www.ncbi.nlm.nih.gov/pubmed/1786500
  6. //www.ncbi.nlm.nih.gov/pubmed/6716406
  7. //www.ncbi.nlm.nih.gov/pubmed/4043326
  8. //www.ncbi.nlm.nih.gov/pubmed/2987637
  9. //www.ncbi.nlm.nih.gov/pubmed/6716406
  10. //www.reddit.com/r/Nootropics/comments/1e26u3/success_story_had_my_first_experience_with/
  11. //www.reddit.com/r/Nootropics/comments/38y40k/my_personal_experience_with_pramiracetam_so_far/
  12. //www.reddit.com/r/Nootropics/comments/p1c2v/pramiracetam_and_alcohol_not_even_once/
Other Scientific Resources (Click to Expand)
  1. //www.ncbi.nlm.nih.gov/pubmed/21202668
  2. //www.ncbi.nlm.nih.gov/pubmed/3088666
  3. //www.ncbi.nlm.nih.gov/pubmed/6716406
  4. //www.ncbi.nlm.nih.gov/pubmed/20166767
  5. //www.ncbi.nlm.nih.gov/pubmed/4008675
  6. //www.ncbi.nlm.nih.gov/pubmed/1473879
  7. //www.ncbi.nlm.nih.gov/pubmed/11387954
  8. //www.ncbi.nlm.nih.gov/pubmed/7586900
  9. //www.ncbi.nlm.nih.gov/pubmed/1688280
  10. //onlinelibrary.wiley.com/doi/10.1002/ddr.430030503/abstract
  11. //www.ncbi.nlm.nih.gov/pubmed/2137359
  12. //www.ncbi.nlm.nih.gov/pubmed/3427459
  13. //www.ncbi.nlm.nih.gov/pubmed/1410129
  14. //www.ncbi.nlm.nih.gov/pubmed/4065299
  15. //www.ncbi.nlm.nih.gov/pubmed/4043326
  16. //www.ncbi.nlm.nih.gov/pubmed/2987637
  17. //www.ncbi.nlm.nih.gov/pubmed/2610714
  18. //www.ncbi.nlm.nih.gov/pubmed/3786350
  19. //www.ncbi.nlm.nih.gov/pubmed/2765166
  20. //www.ncbi.nlm.nih.gov/pubmed/8539328
  21. //www.ncbi.nlm.nih.gov/pubmed/18653001
  22. //www.ncbi.nlm.nih.gov/pubmed/1786500
  23. //www.ncbi.nlm.nih.gov/pubmed/15374306
  24. //www.ncbi.nlm.nih.gov/pubmed/2011259
  25. //www.ncbi.nlm.nih.gov/pubmed/8557218

Author

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  • Peter Tilman

    I’ve had a great experience with pramiracetam, but you are dead on when you recommend capsules. The taste of pram without capsules is just terrible

    • Mansal Denton

      I can’t even tell you how bad it was the first time I did it. Just horrendous.

  • Robert Bryk

    I just ordered this I hope its effects really work on my memory and cognition. Piracetam used to do the trick about 10 years ago but it stopped working.