How (and Why) to Use Psychedelics via Microdosing

How (and Why) to Use Psychedelics via Microdosing

Amidst a sea of overwhelming evidence, psychedelics are making there way back into the mental health conversation. Villainized for decades as a fringe activity for rebels and misfits, it is now becoming a tool for high performance professionals and the traditional medical establishment alike.

After thirty years of living in the shadows, psychedelics are finally starting to get medical credibility. Since the mid-2000s, universities and hospitals have used psychedelics to treat anxiety, depression, post-traumatic stress disorder, and even ease the pain and existential angst of cancer patients.

It was the story of Patrick Mettes, a struggling cancer patient fighting for his life, that captured a new era of psychedelic explorers. Famed food writer, Michael Pollan, discussed the story of Mettes in “The Trip Treatment”, which quickly became one of the most popular articles on the subject in the New Yorker.

The story of a suffering cancer patient easing his pain through psychedelic drugs struck a chord with millions including many popular icons like Tim Ferriss and Joe Rogan.

For those of us who are not suffering from the effects of chemotherapy, treatment resistant depression, or similarly serious ailments, there are cognitive advantages of psychedelics many are starting to seek

Taking small doses of psychedelics (often called “microdosing”), is improving professional work of entrepreneurs, Wall Street traders, and other high mental performance individuals.


What is Microdosing

The idea that small doses of powerful psychedelic drugs can improve cognition is not new. Doctors and researchers worked on the same question in the 1970s and provided plenty of evidence we can relate with today.

Much of this evidence comes from Dr. James Fadiman who led studies in the 1970s, which he explores in his book The Psychedelic Explorer’s Guide. According to him, people across the globe are interested in microdosing and the epicenter seems to be San Francisco.

In a 2015 Rolling Stones article, Fadiman relays how entrepreneurs and technology programmers are using microdosing as a powerful tool. Whereas prescription amphetamine-based drugs like Adderall used to be the go-to, microdosing LSD and psychedelics is becoming an Adderall alternative in Silicon Valley.

Microdosing is the practice of taking small (10-25%) doses of psychedelic drugs in order to improve problem solving skills, enhance creativity, and cognitive performance in general.

These are the most common psychedelics and we will focus on:

  • LSD
  • Psilocybin (and o-acetylpsilocin)
  • MDMA
  • Mescaline


Imagine you wake up in the morning, go through your routine, and get to work on a professional problem you’ve had for weeks. The frustration of working on the same problem without a satisfying result was the basis for a 1966 experiment by James Fadiman on problem solving.

In the experiment, 27 intellectual male subjects (including 16 engineers, 2 mathematicians, 2 architects, 1 engineer-physicist and others) were told to bring a major work-related problem that they hadn’t solved in over 3 months of effort.

The experiment dosed each participant 200 mg of mescaline sulfate and allowed them to work on their difficult problem. Subjectively, almost all reported greater problem-solving skills, but 12 had breakthrough solutions (including patented technology), which is around 44.4% of the sample population.


Adding creativity in a professional setting is incredibly important and more so for musicians and artists. One architect named Eric Clough, who participated in the 1966 study above, said:

The consensus among the architects interviewed…seems to be that LSD, when administered under carefully controlled conditions, does enhance creativity… aids in visualizing three-dimensionally, and generally heightens perceptivity.” (Fadiman, 170)

Mood Enhancement

Most psychedelic drugs interact with the serotonergic system, which modulates mood and can help reduce anxiety and depression symptoms. Psilocybin has already been researched for these purposes even in situations of treatment-resistant depression. Popular icons like Tim Ferriss are supporting this research.

Besides psilocybin, there is evidence that MDMA can be a treatment for post-traumatic stress disorder (PTSD) particularly in the case of military personnel.

Physical Performance

In a book, Tryptamine Palace, author James Oroc writesVirtually all athletes who learn to use LSD… believe that the use of these compounds improves both their stamina and their abilities. According to the combined reports of 40 years of use by the extreme sports underground, LSD can increase your re-flex time to lightning speed, improve your balance to the point of perfection, increase your concentration…

Where his research comes from, we do not know. However, in speaking with a friend (we’ll call him Josh), I received confirmation that both LSD and o-acetylpsilocin (prodrug for psilocin) offered strong physical energy and endurance beyond the norm.

While this is all anecdotal, it suggests some type of physical enhancement while microdosing. In contrast, taking a full or “heroic” dose will not yield these effects (usually the opposite).


Does Microdosing Work?

Whether or not a drug of any kind works will be dependent on many factors including personal biochemistry. There is no one-size fits all answer with microdosing psychedelics, but speaking with friends has yielded a few nuggets of wisdom.

  • Josh: 10 – 12 mcg LSD better for physical endurance and concentration
  • Josh: 12 – 15 mcg LSD better for creative thinking and problem solving.
  • Nathan & Josh: Microdosing 1 x per 3 – 4 days is best (Dr. Fadiman’s recommendation is microdosing once every 4 days).

The anecdotal evidence isn’t all sunshine and rainbows, however. “Gwern” is one of the most well-respected nootropics users and self-experimenters on the internet who did an LSD microdosing experiment that yielded “No beneficial effects…LSD microdosing did not help me.”

Another trained pianist and composer on Reddit took 30 – 40 mcg microdoses and reported “The experience could be described as slightly withdrawn and I felt like I had worse coordination and consequently lower accuracy in playing.”

While the research from Dr. Fadiman in the 1960s is convincing, many of these anecdotes offer a sobering picture. Anyone who is interested in microdosing should consider the entire picture.

How-To: Microdosing, Tips & Tricks

Microdosing with LSD is the most common and it is the easiest. To do so accurately, it’s important to use volumetric dosing

Here is a quick guide you can utilize for your own microdosing experience:

  • Step #1: Weigh out 10 grams of distilled water on the scale
  • Step #2: Mix the water in the pipette bottle with 100 mcg of LSD
  • Step #3: With these calculations (10 g water + 100 mcg LSD), every gram (or ML) of water is now a 10 mcg dose
  • Step #4: Shake up pipette bottle a few minutes before administering (no need to wait all day)

You can use the same method for microdosing with psilocybin, but with this it is harder to extract and measure the doses.

Tip #1 – Don’t cut the LSD tabs in order to create various doses. It’s not an accurate way to divide a dosage due to each tab’s size. More importantly, it doesn’t account for “hotspots”, which are heightened concentrations and uneven distribution of LSD. The volumetric dosing method above resolves both of these problems.

Tip #2 – Some people accidentally take higher doses than they expect when microdosing. 20 mcg of LSD is typically considered on the higher end of the dose range, but some people go as high as 50 mcg. Lower doses of LSD (5 – 12 mcg) have mood boosting advantages and 12 – 20 mcg doses are used for problem-solving and creative work.

If you are using o-acetylpsilocin for a mushroom microdose (easier than trying to weigh actual mushrooms precisely), dosage recommendations are around 3 – 4 mg for microdosing. Just be conscious of your goals when microdosing and use the precise dose for that purpose.

Tip #3 – We recommend not dosing too often. Most recommendations are 3 – 4 days with Dr. Fadiman recommending four. LSD can build tolerance and anecdotal accounts suggest creating uncomfortable relationships with reality.

Tip #4 – Trust your source. This goes without saying, but don’t let your enthusiasm disrupt your judgment.

DISCLAIMER: Neither Nootropedia nor the author recommend, condone, or encourage the use of illicit substances.


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  • I didn’t experience a whole lot on the days that I microdosed. Maybe a little bump in creativity, but not much. I dosed every 4 days for a whole month. The effects that I really noticed were on the second and third days. I had a large spike in creativity and focus. Along with that, the biggest effect was my willpower and a feeling of purpose. Its a little hard to put in to words but I felt more than any other time that I was on the right path and that things just started to click.. Kind of woowoo sounding, but it was really an awesome feeling.

    • Mansal Denton

      Thanks for sharing, Chris! What were the doses you took? Some people have to find the right dosage and that can take a while based on personal biochemistry and genetics.

      In any case, sounds like you had a useful experience even if less quantifiable. Sometimes woo-woo is just lacking explanation, but doesn’t mean it doesn’t exist 🙂

      • Dose was anywhere between 10-30 mcg. It was definitely a useful experience!

  • Cristobaldelicia

    Good article, except for this statement:”it suggests some type of physical enhancement while microdosing. In contrast, taking a full or “heroic” dose will not yield these effects (usually the opposite).” Any significant dose of LSD (or analogs like ALD-52) will improve physical endurance. This can be verified by any music festival fan or rave veteran. I’m sure it is more than anecdotal, and could be verified by 60’s experiments. I’ve felt no need to look them up, because I’ve felt this myself subjectively, and every single person I’ve ever heard or read about confirms the increased energy and stamina. Really I think this reflects badly on Nootropedia. If you have misinformation on a substance with both extensive experimental literature and massive amounts of anecdotal info, how can I trust this source for new, little known and experimental substances?

    • Mansal Denton

      Hey there, let me clarify a bit. First off, there is no valid research on the topic of physical enhancement via psychedelic substances. The info provided is purely anecdotal for your own pleasure.

      Microdosing is often a small enough dose to provide certain benefits (whether cognitive or physical). By taking far larger doses, the feeling is overwhelming and thus makes it difficult to achieve much (physically or “work” wise) though there are other advantages.

      I’ll give you an example. It doesn’t compare 1 to 1, but consider a small dose of caffeine can help you to focus on your work. Too large of a dose will make you completely unfocused, anxious, and jittery. A similar issue exists with psychedelics.

  • c

    where to order? 🙂

    • Mansal Denton

      Hehe, Corey, I’d love to help you there, but afraid I cannot. It’s a pain these days.

      If I had any suggestion it would be to find a deep web / silk road connection. 🙂 Good luck