Summary
Found in a host of plants, hordenine is an alkaloid that interacts with the adrenergic system to promote focus and concentration among others. While the research on hordenine HCl is not conclusive by any means, there is preliminary evidence that this drug can be an adrenaline reuptake inhibitor [1], which makes it a common pairing with other drugs and substances.
Although it is fairly new, hordenine HCl is sold as a fat burner through enhanced metabolism. Unfortunately, few of the studies on hordenine HCl were performed on humans or via oral administration versus injection. Neither of these facts mean that hordenine HCl doesn’t work, but only that hordenine fat burning claims should be taken with a grain of salt.
Also Known As
N, N-dimethyltyramine
Editors’ Thoughts on Hordenine HCl
My only experience taking hordenine HCl is within the Qualia nootropic stack. The ingredient is 20 mg along with 29 others so it is nearly impossible to determine the effects of hordenine HCl alone.
It seems like Qualia also paired the drug with phenylethylamine and some form of AMP Citrate, which does give me some concern. It also makes identifying hordenine even harder (as they are supposed to work together to provide stimulation).
Otherwise, I’m not entirely sure hordenine is worth taking without more human research. It seems to have been popularized for burning fat, though this needs to be confirmed.
Mansal Denton, Nootropedia Editor
Benefits of Hordenine HCl
While it might seem like a synthetic new class of smart drugs, hordenine HCl was discovered and isolated as early as 1894 [2]. Since then, little has been done to adequately research hordenine HCl as it relates to human usage.
A single study in horses found hordenine in their diet, which was acting on their adrenal system [3]. This was the catalyst for more human research, but none of that has led to any results (for either fat burning or improved focus and attention).
Still, plenty of anecdotal reports suggest that hordenine HCl can be an effective stimulant through the adrenergic system. It is often paired with other smart drug compounds (even caffeine) for greater effect.
Looking a bit deeper, the benefit of hordenine HCl is as a noradrenaline reuptake inhibitor [4]. A doubling heart rate is one indicator used to measure this phenomenon in animals [5].
As far as using hordenine HCl for weight loss, there are also few studies suggesting this drug. One insect study showed that hordenine reduced appetite and was a “feeding deterrent” [6]. Of course, eating less is a major role in fat loss.
As a side note (but not pertaining directly to hordenine HCl), other studies showed that hordenine sulfate (different from the hordenine HCl) does not produce any higher quantities of norepinephrine whereas related compounds were able to increase norepinephrine by 36% and 50% [7].
The benefits of hordenine HCl seem interesting as a preworkout or stimulatory agent for some other purpose (professional / work related tasks), but is not necessarily well studied.
Side Effects of Hordenine HCl
From both anecdotal evidence and the scientific literature, there are side effects of hordenine HCl to keep in mind. First, almost anyone who has used this drug finds that it increases heart rate and blood pressure. This makes sense given the mechanism of action (i.e: how it works) so people who have existing heart issues should not take hordenine HCl in combination with other adrenergic drugs (like caffeine, modafinil etc).
Another issue (which is less of a side effect and more of a legal danger) is that hordenine often interacts with morphine / opiate drug tests. Hordenine can cause a false positive for morphine and related opiate drugs [8].
Hordenine HCl Dosage
There are no thorough oral administration studies on hordenine HCl so the dosage is not yet known. Many people anecdotally use a dosage of 10 – 20 mg and it is not something they take daily.
If you are experimenting or trying hordenine HCl, it might be a good idea to take a lower dose and then increase with time as your body shows the capacity to handle such a thing. The dosage should be lowered if you are planning to take adrenaline yielding compounds like caffeine, modafinil or something similar.
How and Where to Buy Hordenine HCl
There are not many places where you can buy hordenine HCl as it is a relatively new substance to hit the marketplace for human consumption. There are few health food or grocery stores that will be willing to carry hordenine HCl so keep that in mind before you start searching.
It’s best to buy hordenine HCl online where you can not only compare the prices, but also see what other community members think about the product. Although we do recommend Pure Nootropics and Nootropics Depot as recommended vendors, neither company currently sells hordenine HCl.
Therefore, based on our analysis of the company and anecdotal reports from community members, we suggest you purchase hordenine HCl via Liftmode. You can find other hordenine HCl for sale online, but this is the safest solution.
Selected Community Experiences
“I have found since posting this, that hordenine lifts my mood amazingly. It has a very mild stim feel, color enhancement, and relaxation. Mix it with my daily weed it makes me blissfull, especially with pea . I take 30-40mg in the mornimg, and 15mg hordenine+300-500 pea at noon to boost my mind and give me some energy.” [9] – Bagnag
“PEA+Hordenine is a horrible stack. It will teach you the meaning of “uncomfortable euphoria”. One reviewer I read (after trying it, unfortunately) said he would compare it unfavorably to meth. Just…don't do it. Definitely not nootropic, and could become highly addictive.” [10] – Flinthearted
- References (Click to Expand)
- //www.ncbi.nlm.nih.gov/pubmed/2570842
- A. Heffter (1894). “Ueber Pellote.” Arch. exp. Path. Pharmakol. 34 65-86.
- //www.ncbi.nlm.nih.gov/pubmed/8582256
- //www.ncbi.nlm.nih.gov/pubmed/4302376
- //www.ncbi.nlm.nih.gov/pubmed/2269269
- K. L. S. Harley (1967). “The influence of plant chemicals on the feeding behavior, development, and survival of the two-striped grasshopper, Melanoplus bivittatus (Sap), Aeridae: Orthoptera.” Can J. Zool. 45 305-319. and E. A. Bernays et al. (2000). “Taste sensitivity of insect herbivores to deterrents is greater in specialists than in generalists: a behavioral test of the hypothesis with two closely related caterpillars.” J. Chem. Ecol. 26 547-563.
- J. W. Daly, C. R. Creveling and B. Witkop (1966). “The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines.” J. Med. Chem. 9 273-280
- //www.ncbi.nlm.nih.gov/pubmed/1618458
- //www.reddit.com/r/Nootropics/comments/17pudo/pea_hordenine/
- //www.reddit.com/r/Nootropics/comments/2i5rhg/pea_hordenine_hcl_amp_citrate/
Hordenine HCL is present in Plexus Accelerator. I did a one week trial of Plexis Slim and Accelerator. I experienced headaches and insomnia almost immediately. On day 4, I began to break out in a rash. For two days I treated it as poison ivy, even though we were very confused because I never had a reaction to poison ivy before and it was not very itchy.
Finished trial and began to research “Plexus rash” and Candida die off. I was beginning to think it either worked miraculously or I was allergic to some component. Rash and swelling spread for more days, closing my right eye. Was taking tons of supplements and activated charcoal.
We had a holiday weekend and I just today, one week after finishing the trial but still having bumps emerge, got in to see my kinesiologist who does muscle testing. Tested negative for poison ivy and Plexus Slim. Tested positive for Plexus Accelerator. This is the ingredient we think is causing my continuing insomnia and possibly allergic reaction. Use with caution.
Hi Chrissand, thanks for your report! Very wise words to be cautious with this ingredient. I agree. Sorry to hear of your experience, though.
Maybe do research BEFORE using a product?
I had thoroughly looked over the Slim but had added the Accelerator last minute decision. So yes, it was a poor choice on my part. But thank you for pointing it out so kindly in a public forum. Very helpful and supportive.
Too many people make statements based on “what they heard from a friend” or read somewhere on the web, without personal experience or valid scientific evidence. Hordenine is a very mild drug and there are no signs that it is physically addictive, especially in oral administration. I take it at up to 400 mg at a time with no unpleasant side effects. It’s a mild stimulant, better than caffeine, as it doesn’t cause the jitters and hyper feeling that caffeine causes. It can boost mood in a mild manner.
Hordenine is present in beer (from hops) and some people are saying it contributes to mood-boosting effects of beer. It’s in barley and many other foods. I’ve taken it with PEA and yes, the combination almost “blew my mind” a couple times, as in causing euphoria and pounding in the head. That doesn’t mean it’s bad; just be careful how much you take. I use many nootropics and I have no comments on its alleged cognitive enhancing effects, as I haven’t tested it for this purpose. I use it sometimes when weight lifting and when I get a “yawny”, tired feeling in the afternoon. I like it, but that doesn’t mean I’ll necessarily keep taking it much in the future.
Personally I don’t play with prepackaged stacks of any kind. I make my own, based on many years of research and trial and error. If you’re trying to make a judgment about hordenine based on its presence in some overhyped commercial stack product, you’re way out of line. That’s no way to evaluate a chemical. Take it by itself, do it yourself, and don’t listen to a bunch of inexperienced know-nothings who just parrot what they’ve heard elsewhere.
Hey there,
Thanks for the comment. I’m not sure who exactly it is directed towards, but I appreciate your personal experience. Sometimes it is nice to have both a scientific background or understanding in addition to anecdotal evidence. Considering there is very little subjective data to be gleaned from a scientific study (with its own flaws), the two combine well.
I am glad you don’t have a strong reaction to hordenine that would render you less likely to utilize it!
People mix it with PEA, that’s where the insane statements come from. when you mix this with PEA…shit gets weird
Eeek! I’ll keep that in mind
as long as ur in USA or canada, phenylethylamine should be legal OTC