DMAE

DMAE is structurally similar to choline, but has one less methyl group. This creates different properties that are said to improve memory and reduce signs of aging in the brain. While not statistically significant, there is some evidence to suggest DMAE can help treat symptoms of Alzheimer’s disease [1].

DMAE supplements are not well absorbed into the brain and this is one of the reasons most people choose to use centrophenoxine instead.

Also Known As

Dimethylaminoethanol, dimethylethanolamine, Deanol (cream)

Editors’ Thoughts on DMAE

I have never used DMAE as I am neither elderly nor in need of another cholinergic. However, if I was going to use this for a family member or myself, I would suggest centrophenoxine instead. This is a classic issue within the nootropics community. Certain drugs don’t get well absorbed so you need prodrugs instead.

Mansal Denton, Nootropedia Editor

Benefits of DMAE

To see the benefits of DMAE, evidence is scarce. Between DMAE and centrophenoxine (a prodrug for DMAE) there is enough evidence to prove therapeutic use for elderly and perhaps young adults alike.

One of the major benefits of DMAE is as an antioxidant. The properties of this drug help to preserve membrane fluidity [2], which has downstream effects on aging in the brain. This helps to prevent beta-amyloid pigmentation to build up [3], which is key for the cognitive protection it offers elderly individuals.

Both centrophenoxine and DMAE have been implicated in supporting symptoms of age-related decline. A study on centrophenoxine showed it could help treat dementia and increased cognitive testing over an 8 week period [4]. A study of 55-90 year olds showed DMAE could improve symptoms of Alzheimer’s disease over 24 weeks [5]. The results were not significant statistically, but does provide some insight.

Side Effects of DMAE

The side effects of DMAE are similar to that of centrophenoxine and risky primarily for women of child rearing age. Although most people using this drug are elderly, DMAE can create (or exacerbate) the formation of neural tube defects [6].

Along the same lines, DMAE may potentially cause teratogenic and should not be taken the first few days after impregnation or women who are attempting to have a child.

DMAE Dosage

The standard DMAE dosage is around 350 mg of DMAE L-Bitartrate powder. There are not many products that have different dosage recommendations, but this is thought to be the best dosage especially for beginners.

How and Where to Buy DMAE

DMAE is not something that you will find in your local health food store and we recommend you buy DMAE online.

Our trusted vendor is Nootropics Depot, where you can buy DMAE with over 350 servings for less than ten dollars. DMAE is one of the most affordable nootropic compounds that you can purchase.

Selected Community Experiences

“Since childhood I’ve suffered from ADD. Initially I was put on methylphenidate from elementary into middle school. After virtually abstaining stimulants in high school, I went on to get prescribed Adderall in college. It greatly increased my performance but kinda made me really anti social especially after the crash. After doing some reading I switched to just strait D – amphetamine, which had its fair share of side effects. After trying virtually every nootropic I could find, I stumbled upon DMAE. DMAE is a choline precursor which i suspect due to its dimethyl group crosses the blood brain barrier very effectively. If I take it in the a.m I feel the effects throughout the day. The benefits include: Sharpness of mind, far better attention, improved reading speed/ comprehension, better social interactions, and less need for sleep. I feel like my brain is turned on like someone increased the volume.” [7] – Neuropharma

References (Click to Expand)

1. //www.ncbi.nlm.nih.gov/pubmed/22330824
2. //www.ncbi.nlm.nih.gov/pubmed/7206814
3. //www.ncbi.nlm.nih.gov/pubmed/8367013
4. //www.ncbi.nlm.nih.gov/pubmed/15374499
5. //www.ncbi.nlm.nih.gov/pubmed/22330824
6. //www.ncbi.nlm.nih.gov/pubmed/11919173
7. //www.reddit.com/r/Nootropics/comments/1y1gvv/dmae_1_week_in_best_treatment_for_add_thus_far/