Aniracetam

Last updated: March 16, 2017

Summary

Your passion for what you do shines through – or maybe you just have a challenging profession. The key is, you are interested in getting better at whatever profession and project you’re working on. Smart drugs, like aniracetam, might help you to achieve it, but first understand the truth.

Aniracetam is an analogue in the racetam family, which was developed after piracetam. Because aniracetam enters the bloodstream quickly [1], it is known as the more potent racetam that can improve memory, cognition as well as improving mood.

While there are fewer aniracetam studies than piracetam, there is evidence to suggest aniracetam can aid in creativity and greater association between concepts (like putting a puzzle together) [2].

Aniracetam is unique because of the unique mood enhancing effects. The nootropic reduces anxiety via interactions with serotonin, dopamine, and choline receptors [3]. Beyond anxiety, there is evidence to suggest it can even be an alternate treatment for depression [4], which is attributed to the main mechanism of action (how it works!)

Largely considered safe and highly effective, aniracetam is a popular nootropic compound that has gained much acclaim through limited research and community anecdotes in recent years.

Also Known As

1-p-anisoyl-2-pyrrilidinone, Ro 13-5057, CAS 72432-10-1, 1(4-methoxybenzoyl)-2-pyrrolidinone

Editors’ Thoughts on Aniracetam

Honestly, I prefer aniracetam over most others in the family. It is more potent than piracetam even though I feel the need to take it more often, but it is not as experimental as phenylpiracetam or pramiracetam, which is largely anecdotal (though very powerful).

The feeling of puzzle pieces coming together is very familiar for me, but more so during physical activity (such as Brazilian jiu-jitsu or AcroYoga). I’ve been very lucky to experience aniracetam with these because I’ve felt my hand-eye coordination to increase.

The drug can also be very exciting in the sense that it is stimulating, but without feeling jittery. I’ve never either taken it or experienced any reduction in anxiety or depression, but those are things I don’t often struggle with anyway.

Mansal Denton, Nootropedia Editor

aniracetam

Aniracetam Benefits

We understand and resonate if you’re asking “what does aniracetam do for me?

How is aniracetam going to make your life better? How will it be a force for good in your life when compared to other nootropics that are available? The aniracetam benefits are manifold and somewhat well documented.

Aniracetam primarily works by exciting certain brain receptors known as AMPA receptors [5]. This uniquely makes aniracetam an anti-anxiety and anti-depression nootropic [6]. Many people who use aniracetam claim it improves their mood and general wellbeing.

The aniracetam smart drug also acts as a strong neuroprotection agent [7]. In one study, the drug helped to improve memory and learning damage in those who struggled with trauma to the brain. Another study showed the aniracetam benefit of protecting against brain trauma as well [8].

Aniracetam is a great memory enhancer through a brain chemical called brain-derived neurotrophic factor (BDNF) [9], which acts as fertilizer for your brain. This is one of the main raw ingredients your brain needs for learning and memory.

Finally, there are benefits of creativity and learning associated with certain parts of the brain. Some consider this effect akin to “putting pieces of a puzzle together” as correlated by both research and anecdotes alike.

There are many purely anecdotal aniracetam benefits, such as effects and interactions with alcohol, improved creativity, and a host of others. Be wary of anecdotal reports, but it is possible for your unique brain chemistry to see more benefits than are adequately researched.

How Does Aniracetam Work?

Each nootropic compound that you ingest has what is referred to as a “mechanism of action”. The aniracetam mechanism of action is essentially how it works to make a change in your brain and body.

Aniracetam is unique because the mechanism of action is more well-known than many others in the family. It is a nootropic that excites the AMPA receptors (ampakines) [10] in the brain. This is the main mechanism that is responsible for the downstream effects, such as improved mood, less anxiety, and reduced depression.

This AMPA modulation of aniracetam also allows for increased BDNF (as described in the benefits section). It is through AMPA (and secondary mechanisms) that aniracetam sees most of its benefits.

Side Effects of Aniracetam

Searching around the internet, you’ve probably found plenty of evidence that nootropic usage is on the rise. The increasing popularity doesn’t necessarily mean the smart drugs are safe to use, but it does show enhanced trust in these cognitive enhancers.

As with any drug, aniracetam side effects can be potentially hazardous and require at least some attention and mindfulness. In the case of aniracetam, it is extremely well-tolerated by humans [11].

Besides the many documented positive side effects of aniracetam, there are some things to keep watch if you are trying the drug for the first time. For one, aniracetam is known to be stimulating or “exciting” in the true sense. It isn’t like caffeine so you won’t go into work with the “shakes”, but it could be much if you are planning to go to sleep afterwards!

In addition to the insomnia, you might find aniracetam side effects such as anxiety or irritability, which are rare, but depend solely on your personal brain biochemistry and the other substances that you have in your system (such as alcohol).

Aniracetam Dosage

Unlike piracetam, which requires a high dosage of many grams per day, aniracetam is highly potent and requires much less. A typical aniracetam dosage might look something like this:

750 mg x twice per day

Keep in mind that aniracetam peaks in your bloodstream around 40 minutes after taking the drug [12], you might want to vary your doses during the hardest work sessions that you have (perhaps 3 – 4 hours apart). That way you can re-up your dosage rather than taking it all at once.

Common Aniracetam Stacks

Aniracetam is a highly potent nootropic, but it does not last long in the bloodstream and up to 95% of the drug is never absorbed [13]. This makes it a great tool for nootropic stacks if you don’t feel it is valuable enough on its own.

Aniracetam Choline Stack – one great nootropic stack is to combine aniracetam and choline. As with most racetam drugs, cholinergic compounds (such as alpha GPC or citicoline) are effective in producing the raw materials that work synergistically with aniracetam.

Aniracetam and Racetam Stack – while aniracetam is short-lived and potent, there are other racetam options that provide a longer, more steady cognitive enhancement. Piracetam has a longer half-life and bioavailability [14], which makes it a great choice in addition to aniracetam.

How and Where to Buy Aniracetam

Like other racetams, you can find aniracetam online for sale, but vendors are not required by United States law to be as careful as popular supplements. Because aniracetam is not regulated by the Food and Drug Administration (FDA), it is important to stay vigilant regarding vendors that you use.

Certain vendors will go above and beyond safety precautions by doing third-party or in-house testing on their products in order to get assay and heavy metals information.

Aniracetam is a synthetic drug, which means it must be made in a laboratory setting. Because most aniracetam is synthesized in China, it is useful to have assay and heavy metals tests to ensure the quality and safety of the products. An assay will determine the percentage of a certain ingredient while the heavy metals will ensure that there is nothing harmful in your product.

Even though aniracetam is popular and you might feel that it is safe to find a cheaper vendor with no testing (such as Absorb Health), just consider that Himalaya Herbal (a multi-national company worth millions of dollars) has produced shady nootropics with heavy metals [15].

Thus, if big brands are not even able to maintain the proper protocols, it is worthwhile to look for testing on all your products, especially aniracetam.

Nootropedia recommends Pure Nootropics aniracetam because business has provided certificates of analysis and third party testing on their capsules and powder.

Selected Community Experiences

While lacking in evidence, sometimes individual experiences from others can be helpful in determining your own.

You might recognize a similar experience to something you’ve had, you might find a side effect you are not willing to risk, so here are a few selected community experiences or aniracetam reviews.

This is the first time i’ve ever taken something that truly has improved my cognitive capacity. My mind has never been so clear. This was my first day taking it. I took 750mg, 3x throughout the day. I have been battling with severe stress, anxiety and depression. For the first time I feel optimistic. I could actually bear myself and to complete my studying/work. [16]- Canibeyourdoctor

Aniracetam has severly reduced my anxiety, has allowed me to take back control of my life and has given me a new sense of purpose through increased mental clarity, focus and motivation. [17]- simplicitea

After a week on Aniracetam i drink way less; It went from getting smashed everynight(8+ Drinks) to me drinking 2 beers a night and feeling content. I hope this isn’t placebo, but even if it is it’s helping me cut down on alcohol consumption. [18]- SativaLungz

References (Click to Expand)
  1. http://www.ncbi.nlm.nih.gov/pubmed/8199398
  2. http://examine.com/supplements/Aniracetam/
  3. http://www.ncbi.nlm.nih.gov/pubmed/11412837
  4. http://www.ncbi.nlm.nih.gov/pubmed/11702095
  5. http://www.ncbi.nlm.nih.gov/pubmed/16182453
  6. http://www.ncbi.nlm.nih.gov/pubmed/11702095
  7. http://www.ncbi.nlm.nih.gov/pubmed/8199398
  8. http://www.ncbi.nlm.nih.gov/pubmed/6817363
  9. http://www.ncbi.nlm.nih.gov/pubmed/10627576
  10. http://www.ncbi.nlm.nih.gov/pubmed/16182453
  11. http://www.ncbi.nlm.nih.gov/pubmed/22070796
  12. http://www.ncbi.nlm.nih.gov/pubmed/8199398
  13. http://www.ncbi.nlm.nih.gov/pubmed/8199398
  14. http://www.ncbi.nlm.nih.gov/pubmed/360232
  15. https://www.reddit.com/r/Nootropics/comments/1n4ac3/himalaya_brand_bacopa/
  16. https://www.reddit.com/r/Nootropics/comments/43dm0f/aniracetam_my_personal_impression_my_life_has/
  17. https://www.reddit.com/r/Nootropics/comments/1glhwd/first_week_on_aniracetam_a_changed_man/
  18. https://www.reddit.com/r/Nootropics/comments/2rdph6/aniracetam_helped_me_gain_self_control/
Other Scientific Resources (Click to Expand)
  1. http://www.ncbi.nlm.nih.gov/pubmed/8199398
  2. http://www.ncbi.nlm.nih.gov/pubmed/8032872
  3. http://www.ncbi.nlm.nih.gov/pubmed/9572910
  4. https://www.zotero.org/geardoc/items/itemKey/EK84J4ZB
  5. http://www.ncbi.nlm.nih.gov/pubmed/2079514
  6. http://www.ncbi.nlm.nih.gov/pubmed/17826366
  7. http://www.ncbi.nlm.nih.gov/pubmed/10832606
  8. http://www.ncbi.nlm.nih.gov/pubmed/16182453
  9. http://www.ncbi.nlm.nih.gov/pubmed/22106175
  10. http://www.ncbi.nlm.nih.gov/pubmed/9550192
  11. http://www.ncbi.nlm.nih.gov/pubmed/1660156
  12. http://www.ncbi.nlm.nih.gov/pubmed/18221205
  13. http://www.ncbi.nlm.nih.gov/pubmed/1681589
  14. http://www.sciencemag.org/content/254/5029/288.abstract?
  15. http://www.pnas.org/content/88/23/10936
  16. http://www.ncbi.nlm.nih.gov/pubmed/1652446
  17. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189827/
  18. http://www.ncbi.nlm.nih.gov/pubmed/10344525
  19. http://cercor.oxfordjournals.org/content/15/7/921.abstract
  20. http://jn.physiology.org/content/74/6/2329.abstract?
  21. http://www.ncbi.nlm.nih.gov/pubmed/11259610
  22. http://www.ncbi.nlm.nih.gov/pubmed/6535371
  23. http://www.ncbi.nlm.nih.gov/pubmed/6817363
  24. http://www.ncbi.nlm.nih.gov/pubmed/11412837
  25. http://www.ncbi.nlm.nih.gov/pubmed/11702095
  26. http://www.ncbi.nlm.nih.gov/pubmed/17504104
  27. http://www.ncbi.nlm.nih.gov/pubmed/1975272
  28. http://www.ncbi.nlm.nih.gov/pubmed/2987637
  29. http://www.ncbi.nlm.nih.gov/pubmed/10385041
  30. http://www.ncbi.nlm.nih.gov/pubmed/11597608
  31. http://www.ncbi.nlm.nih.gov/pubmed/11959085
  32. http://www.ncbi.nlm.nih.gov/pubmed/10627576

Author

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  • Peter Tilman

    Aniracetam is more potent for me than piracetam. is there anything that is more powerful than aniracetam?

    • Mansal Denton

      Hi Peter, you can try to use things like phenylpiracetam or coluracetam if you are interested in something more potent! Thanks for commenting

  • Ryan Daniels

    Ahhh yeah! Aniracetam is my favorite Nootropic yet. If you guys like Aniracetam definitely test out Piracetam as well as this was very effective for me. Thanks for the information dude, I’ve written my own review of Aniracetam with some data to back up some claims.

    Cheers