Your passion for what you do shines through – or maybe you just have a challenging profession. The key is, you are interested in getting better at whatever profession and project you’re working on. Smart drugs, like aniracetam, might help you to achieve it, but first understand the truth.
Aniracetam is an analogue in the racetam family, which was developed after piracetam. Because aniracetam enters the bloodstream quickly , it is known as the more potent racetam that can improve memory, cognition as well as improving mood.
While there are fewer aniracetam studies than piracetam, there is evidence to suggest aniracetam can aid in creativity and greater association between concepts (like putting a puzzle together) .
Aniracetam is unique because of the unique mood enhancing effects. The nootropic reduces anxiety via interactions with serotonin, dopamine, and choline receptors . Beyond anxiety, there is evidence to suggest it can even be an alternate treatment for depression , which is attributed to the main mechanism of action (how it works!)
Largely considered safe and highly effective, aniracetam is a popular nootropic compound that has gained much acclaim through limited research and community anecdotes in recent years.
Also Known As
1-p-anisoyl-2-pyrrilidinone, Ro 13-5057, CAS 72432-10-1, 1(4-methoxybenzoyl)-2-pyrrolidinone
We understand and resonate if you’re asking “what does aniracetam do for me?”
How is aniracetam going to make your life better? How will it be a force for good in your life when compared to other nootropics that are available? The aniracetam benefits are manifold and somewhat well documented.
Aniracetam primarily works by exciting certain brain receptors known as AMPA receptors . This uniquely makes aniracetam an anti-anxiety and anti-depression nootropic . Many people who use aniracetam claim it improves their mood and general wellbeing.
The aniracetam smart drug also acts as a strong neuroprotection agent . In one study, the drug helped to improve memory and learning damage in those who struggled with trauma to the brain. Another study showed the aniracetam benefit of protecting against brain trauma as well .
This nootropic is a great memory enhancer through a brain chemical called brain-derived neurotrophic factor (BDNF) , which acts as fertilizer for your brain. This is one of the main raw ingredients your brain needs for learning and memory.
Finally, there are benefits of creativity and learning associated with certain parts of the brain. Some consider this effect akin to “putting pieces of a puzzle together” as correlated by both research and anecdotes alike.
There are many purely anecdotal aniracetam benefits, such as effects and interactions with alcohol, improved creativity, and a host of others. Be wary of anecdotal reports, but it is possible for your unique brain chemistry to see more benefits than are adequately researched.
How Does Aniracetam Work?
Each nootropic compound that you ingest has what is referred to as a “mechanism of action”. The aniracetam mechanism of action is essentially how it works to make a change in your brain and body.
This nootropic is unique because the mechanism of action is more well-known than many others in the family. It is a nootropic that excites the AMPA receptors (ampakines)  in the brain. This is the main mechanism that is responsible for the downstream effects, such as improved mood, less anxiety, and reduced depression.
This AMPA modulation of aniracetam also allows for increased BDNF (as described in the benefits section). It is through AMPA (and secondary mechanisms) that aniracetam sees most of its benefits.
Side Effects of Aniracetam
Searching around the internet, you’ve probably found plenty of evidence that nootropic usage is on the rise. The increasing popularity doesn’t necessarily mean the smart drugs are safe to use, but it does show enhanced trust in these cognitive enhancers.
As with any drug, aniracetam side effects can be potentially hazardous and require at least some attention and mindfulness. In this case, it is extremely well-tolerated by humans .
Besides the many documented positive side effects of aniracetam, there are some things to keep watch if you are trying the drug for the first time. For one, aniracetam is known to be stimulating or “exciting” in the true sense. It isn’t like caffeine so you won’t go into work with the “shakes”, but it could be much if you are planning to go to sleep afterwards!
In addition to the insomnia, you might find aniracetam side effects such as anxiety or irritability, which are rare, but depend solely on your personal brain biochemistry and the other substances that you have in your system (such as alcohol).
Unlike piracetam, which requires a high dosage of many grams per day, aniracetam is highly potent and requires much less. A typical aniracetam dosage might look something like this:
750 mg x twice per day
Recommended aniracetam dosage: 750 mg x 2 servings per day
Aniracetam is considered a more potent and fast-acting member of the racetam family. The right aniracetam dosage will depend on your desires and personal biochemistry, but listed above is a good starting point.
Mechanisms of Aniracetam
The reason the aniracetam dosage matters is because aniracetam is unique from other drugs in the family. Piracetam and aniracetam have widely varied dosages because of the differences in their mechanism.
Aniracetam is quickly absorbed into the bloodstream and has a short half life , which makes it a potent tool for focus and concentration benefits. Many people who use aniracetam on internet communities note that it is an incredibly effective tool for this purpose.
Although the recommended aniracetam dosage is around 750 mg x 2 servings, you may be better off taking more servings than two because of the stimulating effects. You may want to take upwards of 3 – 4 servings of smaller doses to get the full effects.
Heroic Aniracetam Dosage
Within the scientific literature, the effects of aniracetam seem to be related to AMPA modulation . This has a significant impact on cognitive abilities and primarily in the realms of anti-anxiety, reducing feelings of depression, and similar mood related ailments.
It is rare, but some people on the internet communities of Reddit and Longecity use heroic aniracetam dosages in order to test their persona brain chemistry on high doses. We do not recommend that you try this, but it is a trend given that racetams are considered particularly safe compared to other nootropic compounds.
Some of the feedback that we have seen regarding aniracetam has been very high. For example, one of the quotes that we have found regarding the topic suggests:
“Aniracetam has severly reduced my anxiety, has allowed me to take back control of my life and has given me a new sense of purpose through increased mental clarity, focus and motivation.” – simplicitea
It is helpful to see that people are using the aniracetam dosage effectively and seeing cognitive advantages of doing so.
Keep in mind that aniracetam peaks in your bloodstream around 40 minutes after taking the drug , you might want to vary your doses during the hardest work sessions that you have (perhaps 3 – 4 hours apart). That way you can re-up your dosage rather than taking it all at once.
Many beginners use a small aniracetam dosage so as to avoid the risk of adverse effects. Even a normal aniracetam dosage will probably cause few side effects, but it is worthwhile for beginners to protect themselves in any way possible.
- References (Click to Expand)
Common Aniracetam Stacks
Aniracetam is a highly potent nootropic, but it does not last long in the bloodstream and up to 95% of the drug is never absorbed . This makes it a great tool for nootropic stacks if you don’t feel it is valuable enough on its own.
One great method of using aniracetam is alongside mitochondrial supplements so there is an added boosting effect on overall health not just short-term stimulation.
Aniracetam Choline Stack – one great nootropic stack is to combine aniracetam and choline. As with most racetam drugs, cholinergic compounds (such as alpha GPC or citicoline) are effective in producing the raw materials that work synergistically with aniracetam.
Aniracetam and Racetam Stack – while this nootropic is short-lived and potent, there are other racetam options that provide a longer, more steady cognitive enhancement. Piracetam has a longer half-life and bioavailability , which makes it a great choice in addition to aniracetam. There are other racetams that can be effective as well (such as phenylpiracetam, oxiracetam, and pramiracetam). Consider which racetam to combine with care, however. Some of these can be highly stimulating and when combined can become overwhelming.
Aniracetam and -afinil Stack – for a multitude of reasons, modafinil is a highly popular nootropic compound and stimulant. It's so popular, many people use it as an Adderall alternative. It can be combined with aniracetam because they have varied mechanisms in the brain. People will often take modafinil (or cousins adrafinil and armodafinil) in order to have mental stimulation and focus while the aniracetam helps with memory formation and learning.
Aniracetam and Unique Blends – for legal reasons, most unique blend nootropic stacks do not have aniracetam inside. Things like Qualia, Alpha Brain, Mind Lab Pro, and others do not have any racetam, which means it is possible to combine them. Be careful with the number of ingredients you consume, however. Unique blends (especially those with proprietary blends) can include many ingredients and sometimes the interactions between all of them (and aniracetam) can create side effects.
Aniracetam and Nutrient Stack – another common combination is to have aniracetam with many of the nutrients that we do not have enough of in our modern diet. Things like magnesium glycinate (or magnesium threonate) are helpful. Other people benefit from methylfolate or vitamin D because of deficiencies in these major nutrients. Finally, because aniracetam is fat soluble, it is possible to use it alongside a ketogenic diet (where beta-hydroxybutyrate might be useful).
How and Where to Buy Aniracetam
Like other racetams, you can find aniracetam online for sale, but vendors are not required by United States law to be as careful as popular supplements. Because this nootropic is not regulated by the Food and Drug Administration (FDA), it is important to stay vigilant regarding vendors that you use.
Certain vendors will go above and beyond safety precautions by doing third-party or in-house testing on their products in order to get assay and heavy metals information.
Aniracetam is a synthetic drug, which means it must be made in a laboratory setting. Because this nootropic is synthesized in China, it is useful to have assay and heavy metals tests to ensure the quality and safety of the products. An assay will determine the percentage of a certain ingredient while the heavy metals will ensure that there is nothing harmful in your product.
Even though this drug is popular and you might feel that it is safe to find a cheaper vendor with no testing (such as Absorb Health), just consider that Himalaya Herbal (a multi-national company worth millions of dollars) has produced shady nootropics with heavy metals .
Thus, if big brands are not even able to maintain the proper protocols, it is worthwhile to look for testing on all your products, especially the racetams.
Nootropedia recommends Pure Nootropics aniracetam because business has provided certificates of analysis and third party testing on their capsules and powder.
Most aniracetam reviews are positive indicating that this nootropic drug is useful for the following purposes:
- Concentration and attentiveness
- Creativity and complex thinking
- Memory formation and learning ability
- Social anxiety and symptoms of depression
Some of the online aniracetam reviews correlate directly with the research findings in scientific studies, but others do not. Throughout this article, we will show you how effective (or ineffective) aniracetam is for improving cognitive performance.
Aniracetam Reviews: Does This Nootropic Work?
According to most of the reviews online, aniracetam does work quite well. In fact, because it enters the bloodstream so quickly and reaches peak concentrations in the brain, it can be more popular than piracetam, which usually comes with little “feeling” or noticeable effects.
Many people who use aniracetam claim that it is felt within 15 – 20 minutes, helps to increase mental stimulation, creative output, and a host of other mental markers vastly different than a simple cup of coffee.
As other quotes have said, there is a significant anti-anxiety (anxiolytic) effect that comes with aniracetam as well. Many people use it simply to feel more at ease and relaxed.
Note that there are plenty of people who also experience either nothing or negative effects. For example, some people that I know will take aniracetam and feel nothing so they feel as they nothing has happened. While this might be true (for them), it is also hard to measure without any kind of tools.
The truth is, aniracetam may or may not work for you, but until you buy aniracetam and try it for yourself, you’ll never find out.
What Does Science Say?
For some people skeptical of online aniracetam reviews, the scientific literature is more convincing.
The mood benefits are clearly seen through a couple aniracetam studies. In one European Journal of Pharmacology study, scientists discovered that aniracetam could help reduce anxiety via cholinergic, dopaminergic, and serotonergic systems within the brain .
In another 2001 Psychopharmacology journal, scientists concluded that aniracetam had antidepressant effects especially after a stroke .
There is also evidence that aniracetam can help with learning ability, neuroprotection, and even increasing brain derived neurotrophic factor (BDNF), which is like fertilizer for the brain .
The study is pretty conclusive that aniracetam does work for improving cognitive markers, but there aren’t enough studies on healthy adult humans to say one way or another. Unfortunately, there is too little scientific evidence to say definitively, but this is the case with nearly every nootropic drug out there.
There is barely enough money to research the medications that save lives (such as cancer and Alzheimer’s disease) so there is even less money for studying cognitive enhancement in healthy adults. This is where the aniracetam reviews are not only useful, but imperative for us to see what is possible.
Aniracetam Reviews Online
Most of the aniracetam reviews online are very positive. Even though aniracetam is in limbo as far as the legal status, it is consumed in high quantities rivaling that of piracetam (the grandfather of this drug).
The most stellar reviews of aniracetam come from places you might not expect it, such as large media personalities within the biohacking and nootropics space. For example, Jesse Lawler has discussed using aniracetam as part of his “creativity” stack during a recent interview .
As the host of the Smart Drug Smarts podcast, it is interesting to note that Lawler does not use many nootropics (he mentions less than 5 throughout the interview), but he does count aniracetam among his close few.
Another popular personality is Dave Asprey (otherwise known as the Bulletproof Executive). He has made butter coffee famous lately, but he is also a proponent of nootropics (and not only modafinil). In one article, he declared:
“I like aniracetam more than piracetam because it’s the only member of the racetam that has a stress-lowering effect and also increase memory IO (getting memories in and out of your mind). I take aniracetam every day, as well as for public speaking. I find I speak more fluently (no “ums” or “ahs”) and I don’t have to grasp for words…” .
Of course, beyond the well known people within the space, there are plenty of people that have positive things to say about aniracetam.
Here is an aniracetam review from “silverhydra”, which is the pseudonym for Kurtis Frank (editor of Examine.com):
“Ani is also my racetam of choice (only one I've liked, although I have not used nefi or pira yet), and mostly it is because it seems to be a combination of a social anxiolytic and ‘silver tongue granter' (not really a silver tongue, but words come easier) which are two cognitive realms I usually suck at. Now that you mention awareness I guess that goes up as well, never really examined it…” 
Evaluating Aniracetam Reviews
Even though there is plenty of anecdotal evidence to suggest aniracetam is effective for enhancing cognitive abilities, we must evaluate these instances carefully. For example, what works well for one person may not work as well for you.
Every brain is different and we each have unique brain chemistry. Here is a specific aniracetam review from a user on the nootropic community called Reddit:
“Last night I tried for the first time, one tablet of 750mg taken with fish oil and yoghurt. About 30mins in I started feeling a little foggy, then within one hour I was downright tired, disoriented and nauseous! I had to lay down on the couch, and couldn't even use/read on my phone. A headache started so I quickly took an Ibux to avoid it escalating into something like a migraine. This did go away but still I just felt like going to bed and that was it….” 
As many people within that thread mention, it could have simply been a lack of choline that caused the side effects, but that is something for you to consider as well.
Much of the anecdotal evidence is important to make cognitive enhancement decisions, but many of these experiences / opinions are single stories (or a data set of n = 1, which means only 1 subject for the experiment).
Selected Community Experiences
While lacking in evidence, sometimes individual experiences from others can be helpful in determining your own.
You might recognize a similar experience to something you’ve had, you might find a side effect you are not willing to risk, so here are a few selected community experiences or aniracetam reviews.
“This is the first time i've ever taken something that truly has improved my cognitive capacity. My mind has never been so clear. This was my first day taking it. I took 750mg, 3x throughout the day. I have been battling with severe stress, anxiety and depression. For the first time I feel optimistic. I could actually bear myself and to complete my studying/work.” - Canibeyourdoctor
“Aniracetam has severly reduced my anxiety, has allowed me to take back control of my life and has given me a new sense of purpose through increased mental clarity, focus and motivation.” - simplicitea
“After a week on Aniracetam i drink way less; It went from getting smashed everynight(8+ Drinks) to me drinking 2 beers a night and feeling content. I hope this isn't placebo, but even if it is it's helping me cut down on alcohol consumption.” - SativaLungz
Nootropedia Disclaimer: While we support psychedelic science and support usage of entheogens like ayahuasca (DMT) and psilocybin, it is recommended to avoid using other substances such as aniracetam alongside them. We do not recommend using them together.
- References (Click to Expand)
Author’s Thoughts on Aniracetam
Honestly, I prefer aniracetam over most others in the family. It is more potent than piracetam even though I feel the need to take it more often, but it is not as experimental as phenylpiracetam or pramiracetam, which is largely anecdotal (though very powerful).
The feeling of puzzle pieces coming together is very familiar for me, but more so during physical activity (such as Brazilian jiu-jitsu or AcroYoga). I’ve been very lucky to experience aniracetam with these because I’ve felt my hand-eye coordination to increase.
The drug can also be very exciting in the sense that it is stimulating, but without feeling jittery. I’ve never either taken it or experienced any reduction in anxiety or depression, but those are things I don’t often struggle with anyway.
Mansal Denton, Nootropedia Contributor
- References (Click to Expand)
- Other Scientific Resources (Click to Expand)