Aniracetam

Last updated: October 11, 2018

Summary

Your passion for what you do shines through – or maybe you just have a challenging profession. The key is, you are interested in getting better at whatever profession and project you’re working on. Smart drugs, like aniracetam, might help you to achieve it, but first understand the truth.

Aniracetam is an analogue in the racetam family, which was developed after piracetam. Because aniracetam enters the bloodstream quickly [1], it is known as the more potent racetam that can improve memory, cognition as well as improving mood.

While there are fewer aniracetam studies than piracetam, there is evidence to suggest aniracetam can aid in creativity and greater association between concepts (like putting a puzzle together) [2].

Aniracetam is unique because of the unique mood enhancing effects. The nootropic reduces anxiety via interactions with serotonin, dopamine, and choline receptors [3]. Beyond anxiety, there is evidence to suggest it can even be an alternate treatment for depression [4], which is attributed to the main mechanism of action (how it works!)

Largely considered safe and highly effective, aniracetam is a popular nootropic compound that has gained much acclaim through limited research and community anecdotes in recent years.

Also Known As

1-p-anisoyl-2-pyrrilidinone, Ro 13-5057, CAS 72432-10-1, 1(4-methoxybenzoyl)-2-pyrrolidinone

Editors’ Thoughts on Aniracetam

Honestly, I prefer aniracetam over most others in the family. It is more potent than piracetam even though I feel the need to take it more often, but it is not as experimental as phenylpiracetam or pramiracetam, which is largely anecdotal (though very powerful).

The feeling of puzzle pieces coming together is very familiar for me, but more so during physical activity (such as Brazilian jiu-jitsu or AcroYoga). I’ve been very lucky to experience aniracetam with these because I’ve felt my hand-eye coordination to increase.

The drug can also be very exciting in the sense that it is stimulating, but without feeling jittery. I’ve never either taken it or experienced any reduction in anxiety or depression, but those are things I don’t often struggle with anyway.

Mansal Denton, Nootropedia Editor

aniracetam

Aniracetam Benefits

We understand and resonate if you’re asking “what does aniracetam do for me?

How is aniracetam going to make your life better? How will it be a force for good in your life when compared to other nootropics that are available? The aniracetam benefits are manifold and somewhat well documented.

Aniracetam primarily works by exciting certain brain receptors known as AMPA receptors [5]. This uniquely makes aniracetam an anti-anxiety and anti-depression nootropic [6]. Many people who use aniracetam claim it improves their mood and general wellbeing.

The aniracetam smart drug also acts as a strong neuroprotection agent [7]. In one study, the drug helped to improve memory and learning damage in those who struggled with trauma to the brain. Another study showed the aniracetam benefit of protecting against brain trauma as well [8].

This nootropic is a great memory enhancer through a brain chemical called brain-derived neurotrophic factor (BDNF) [9], which acts as fertilizer for your brain. This is one of the main raw ingredients your brain needs for learning and memory.

Finally, there are benefits of creativity and learning associated with certain parts of the brain. Some consider this effect akin to “putting pieces of a puzzle together” as correlated by both research and anecdotes alike.

There are many purely anecdotal aniracetam benefits, such as effects and interactions with alcohol, improved creativity, and a host of others. Be wary of anecdotal reports, but it is possible for your unique brain chemistry to see more benefits than are adequately researched.

How Does Aniracetam Work?

Each nootropic compound that you ingest has what is referred to as a “mechanism of action”. The aniracetam mechanism of action is essentially how it works to make a change in your brain and body.

This nootropic is unique because the mechanism of action is more well-known than many others in the family. It is a nootropic that excites the AMPA receptors (ampakines) [10] in the brain. This is the main mechanism that is responsible for the downstream effects, such as improved mood, less anxiety, and reduced depression.

This AMPA modulation of aniracetam also allows for increased BDNF (as described in the benefits section). It is through AMPA (and secondary mechanisms) that aniracetam sees most of its benefits.

Side Effects of Aniracetam

Searching around the internet, you’ve probably found plenty of evidence that nootropic usage is on the rise. The increasing popularity doesn’t necessarily mean the smart drugs are safe to use, but it does show enhanced trust in these cognitive enhancers.

As with any drug, aniracetam side effects can be potentially hazardous and require at least some attention and mindfulness. In this case, it is extremely well-tolerated by humans [11].

Besides the many documented positive side effects of aniracetam, there are some things to keep watch if you are trying the drug for the first time. For one, aniracetam is known to be stimulating or “exciting” in the true sense. It isn’t like caffeine so you won’t go into work with the “shakes”, but it could be much if you are planning to go to sleep afterwards!

In addition to the insomnia, you might find aniracetam side effects such as anxiety or irritability, which are rare, but depend solely on your personal brain biochemistry and the other substances that you have in your system (such as alcohol).

Aniracetam Dosage

Unlike piracetam, which requires a high dosage of many grams per day, aniracetam is highly potent and requires much less. A typical aniracetam dosage might look something like this:

750 mg x twice per day

Keep in mind that aniracetam peaks in your bloodstream around 40 minutes after taking the drug [12], you might want to vary your doses during the hardest work sessions that you have (perhaps 3 – 4 hours apart). That way you can re-up your dosage rather than taking it all at once.

Many beginners use a small aniracetam dosage so as to avoid the risk of adverse effects. Even a normal aniracetam dosage will probably cause few side effects, but it is worthwhile for beginners to protect themselves in any way possible.

Common Aniracetam Stacks

Aniracetam is a highly potent nootropic, but it does not last long in the bloodstream and up to 95% of the drug is never absorbed [13]. This makes it a great tool for nootropic stacks if you don’t feel it is valuable enough on its own.

One great method of using aniracetam is alongside mitochondrial supplements so there is an added boosting effect on overall health not just short-term stimulation.

Aniracetam Choline Stack – one great nootropic stack is to combine aniracetam and choline. As with most racetam drugs, cholinergic compounds (such as alpha GPC or citicoline) are effective in producing the raw materials that work synergistically with aniracetam.

Aniracetam and Racetam Stack – while this nootropic is short-lived and potent, there are other racetam options that provide a longer, more steady cognitive enhancement. Piracetam has a longer half-life and bioavailability [14], which makes it a great choice in addition to aniracetam. There are other racetams that can be effective as well (such as phenylpiracetam, oxiracetam, and pramiracetam). Consider which racetam to combine with care, however. Some of these can be highly stimulating and when combined can become overwhelming. 

Aniracetam and -afinil Stack – for a multitude of reasons, modafinil is a highly popular nootropic compound and stimulant. It’s so popular, many people use it as an Adderall alternative. It can be combined with aniracetam because they have varied mechanisms in the brain. People will often take modafinil (or cousins adrafinil and armodafinil) in order to have mental stimulation and focus while the aniracetam helps with memory formation and learning.

Aniracetam and Unique Blends – for legal reasons, most unique blend nootropic stacks do not have aniracetam inside. Things like Qualia, Alpha Brain, Mind Lab Pro, and others do not have any racetam, which means it is possible to combine them. Be careful with the number of ingredients you consume, however. Unique blends (especially those with proprietary blends) can include many ingredients and sometimes the interactions between all of them (and aniracetam) can create side effects.

Aniracetam and Nutrient Stack – another common combination is to have aniracetam with many of the nutrients that we do not have enough of in our modern diet. Things like magnesium glycinate (or magnesium threonate) are helpful. Other people benefit from methylfolate or vitamin D because of deficiencies in these major nutrients. Finally, because aniracetam is fat soluble, it is possible to use it alongside a ketogenic diet (where beta-hydroxybutyrate might be useful).

How and Where to Buy Aniracetam

Like other racetams, you can find aniracetam online for sale, but vendors are not required by United States law to be as careful as popular supplements. Because this nootropic is not regulated by the Food and Drug Administration (FDA), it is important to stay vigilant regarding vendors that you use.

Certain vendors will go above and beyond safety precautions by doing third-party or in-house testing on their products in order to get assay and heavy metals information.

Aniracetam is a synthetic drug, which means it must be made in a laboratory setting. Because this nootropic is synthesized in China, it is useful to have assay and heavy metals tests to ensure the quality and safety of the products. An assay will determine the percentage of a certain ingredient while the heavy metals will ensure that there is nothing harmful in your product.

Even though this drug is popular and you might feel that it is safe to find a cheaper vendor with no testing (such as Absorb Health), just consider that Himalaya Herbal (a multi-national company worth millions of dollars) has produced shady nootropics with heavy metals [15].

Thus, if big brands are not even able to maintain the proper protocols, it is worthwhile to look for testing on all your products, especially the racetams.

Nootropedia recommends Pure Nootropics aniracetam because business has provided certificates of analysis and third party testing on their capsules and powder.

Selected Community Experiences

While lacking in evidence, sometimes individual experiences from others can be helpful in determining your own.

You might recognize a similar experience to something you’ve had, you might find a side effect you are not willing to risk, so here are a few selected community experiences or aniracetam reviews.

This is the first time i’ve ever taken something that truly has improved my cognitive capacity. My mind has never been so clear. This was my first day taking it. I took 750mg, 3x throughout the day. I have been battling with severe stress, anxiety and depression. For the first time I feel optimistic. I could actually bear myself and to complete my studying/work. [16]- Canibeyourdoctor

Aniracetam has severly reduced my anxiety, has allowed me to take back control of my life and has given me a new sense of purpose through increased mental clarity, focus and motivation. [17]- simplicitea

After a week on Aniracetam i drink way less; It went from getting smashed everynight(8+ Drinks) to me drinking 2 beers a night and feeling content. I hope this isn’t placebo, but even if it is it’s helping me cut down on alcohol consumption. [18]- SativaLungz

Aniracetam Reviews

The aniracetam reviews above are important due to the lack of scientific literature on healthy adults seeking cognitive enhancement. While there are some studies on healthy adults, most focus on the aniracetam effects with patients struggling with memory loss or dementia.

Few readers have this immediate problem, which is why the anecdotal evidence from the community can help make better decisions. Although aniracetam reviews alone are not a good basis for making your decisions, it can help you to create expectations for the drug.

Take all of the aniracetam reviews with a grain of salt, but do not discount them as valid information for which to make nootropics decisions.

Nootropedia Disclaimer: While we support psychedelic science and support usage of entheogens like ayahuasca (DMT) and psilocybin, it is recommended to avoid using other substances such as aniracetam alongside them. We do not recommend using them together. 

References (Click to Expand)
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Other Scientific Resources (Click to Expand)
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Author

Mansal Denton is the founder of Nootropedia on a quest to inform users on effectively utilizing nootropics and smart drugs. His work has been featured in Forbes, Inc, Entrepreneur, and Vice.