Adrafinil vs. Modafinil: One of These is Better Than the Other

Summary

When comparing adrafinil vs. modafinil there are subtle differences between the two that have drastic consequences for the efficacy of the drug.

Modafinil is usually considered more effective than adrafinil.

This conclusion is based on adrafinil’s mechanism, which is to be converted by the liver into modafinil. Most people (including the French drug administration) believe the added stress to the liver to not be worth the risks.

Studies On Adrafinil vs. Modafinil

Most of the scientific research is currently done on modafinil. This does not mean adrafinil does not work. In fact, adrafinil works so well because modafinil is well-researched and understood. The main mechanism for adrafinil is to convert into modafinil through the liver process and then improve cognition.

Despite this process, there are slight differences between adrafinil and modafinil. To find out more about these differences, you must visit online communities such as Reddit and Longecity. The subjective experiences of people within these communities will teach you about the differences even though they must be taken with a grain of salt.

Either way, the evidence suggests that modafinil is a potent and useful cognitive enhancer. Studies show it is as powerful as amphetamine-based drugs for treating cognitive fatigue and mood degradation that comes from sleep deprivation [1].

Modafinil (and by proxy, adrafinil) works via a few different mechanisms. Modafinil is influenced by dopaminergic activity [2], which is similar to other related drugs, but not nearly as bad. This is one of the reasons why modafinil (also known as provigil) is used as a drug for wakefulness instead of Adderall. It is strong and effective, but without as many side effects (note: that doesn’t mean there are no side effects).

Side Effects of Adrafinil and Modafinil

The potency of these drugs makes them susceptible to side effects as well. If you are taking adrafinil and modafinil, there may be feelings of irritability and anxiety or even nausea and gastrointestinal distress. Some people online complain (or laud) the appetite suppression that often comes from these types of nootropic drugs.

Other people experience congestion and allergy-like symptoms using modafinil due to the histiminergic activity. It can seem like an allergy, but is actually modafinil-induced allergies to some degree (this is something the author experienced using the drug).

For adrafinil especially, the worry is that there will be side effects for the liver. People complain that by taking a drug that gets converted in the liver, it is problematic for the liver. While this might be a concern in theory, it will depend on the person.

One Redditor did a liver test over time alongside adrafinil supplementation and found no differences in health. This may have been too short of a period and it was only a single sample, but is interesting nonetheless.

One Benefit of Adrafinil

One of the major benefits of adrafinil is the fact that it is still unregulated and considered legal. Most people do not realize that modafinil is technically a scheduled drug as it requires a prescription to take. While it is easy to purchase modafinil online, it is better that you get prescription to be safe within the bounds of the law.

However, adrafinil is unregulated and thus can be taken without any kind of documentation or prescription.

The true test of adrafinil vs. modafinil is related to your perception of risk and legality. Adrafinil is by far less effective than modafinil when taken purely for the psychoactive effects. After all, adrafinil is only useful so that it can create modafinil within the liver.

If you have no problem with breaking the law, modafinil is definitely the safer way to go for your body and long-term health (though it is still an intense, stimulant-based drug). The repercussions for buying and using modafinil are quite few and far between at present.

Anecdotes of millions of people on Reddit and Longecity suggest that modafinil is not often regulated upon importation. Purchasing from overseas makes it easy to get an individual dosage of the drug and then use it for personal use. Few individuals have gotten into trouble for using the drug and at most it may be a fine.

We are not encouraging the usage of modafinil over adrafinil (given that it is a regulated substance in the United States), but we do want to paint a realistic portrayal of the issue. The legal nature of the drug should not too harshly interfere with your own personal health. Taking adrafinil may not be detrimental to your health per se, but it probably is more risk than modafinil and that’s more than you need!

References (Click to Expand)
  1. http://www.ncbi.nlm.nih.gov/pubmed/10607161
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696807/